正常及同种异型抑制杂合兔细胞表面和血清免疫球蛋白中κ链同种异型的表达。
Expression of kappa chain allotypes at the cell surface and in serum immunoglobulins of normal and allotype-suppressed heterozygous rabbits.
作者信息
Abdi H B, Simons M A, Young-Cooper G O, Mage R G
出版信息
Immunology. 1982 Jul;46(3):661-9.
The kappa light chain allotypes b4 and b5 were measured in the serum and on the surfaces of peripheral blood lymphocytes of normal and allotype-suppressed heterozygous rabbits. Surface immunoglobulins (sIg) were detected by fluorescence microscopy and additional quantitative data were obtained by flow microfluorometry. Although a few b5-suppressed animals had no b5 in serum or on cell surfaces for years, most b5-suppressed and all b4-suppressed animals studied had some cells with sIg of the suppressed type by 1 year of age. In suppressed animals the level of serum Ig remained depressed throughout life but cells with sIg appeared in disproportionately large numbers. The effect was particularly striking in those animals suppressed for the b4 type.
在正常和同种异型抑制的杂合兔的血清及外周血淋巴细胞表面，检测了κ轻链同种异型b4和b5。通过荧光显微镜检测表面免疫球蛋白（sIg），并通过流式微量荧光测定法获得额外的定量数据。尽管一些b5抑制的动物多年来血清或细胞表面均无b5，但大多数研究的b5抑制动物和所有b4抑制动物在1岁时，都有一些带有被抑制类型sIg的细胞。在抑制的动物中，血清Ig水平终生保持降低，但带有sIg的细胞数量却不成比例地大量出现。这种效应在那些被抑制为b4类型的动物中尤为显著。
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