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Prostaglandin prodrugs. I: Stabilization of dinoprostone (prostaglandin E2) in solid state through formation of crystalline C1-phenyl esters.

作者信息

Morozowich W, Oesterling T O, Miller W L, Lawson C F, Weeks J R, Stehle R G, Douglas S L

出版信息

J Pharm Sci. 1979 Jul;68(7):833-6. doi: 10.1002/jps.2600680711.

DOI:10.1002/jps.2600680711
PMID:458598
Abstract

Dinoprostone para-substituted phenyl esters were synthesized in attempt to improve the solid-state stability of the parent prostaglandin. A phenol series covering a wide melting-point range was employed, and a linear relationship was observed between the phenol melting points and the resulting prostaglandin C1-ester melting points. The crystalline esters showed improved solid-state stability over the parent compound, and many esters were biologically active.

摘要

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