多烯抗生素的选择性膜毒性：对天然膜的研究
Selective membrane toxicity of the polyene antibiotics: studies on natural membranes.
作者信息
Hsuchen C C, Feingold D S
出版信息
Antimicrob Agents Chemother. 1973 Sep;4(3):316-9. doi: 10.1128/AAC.4.3.316.
Abstract
The effect of polyene antibiotics on Candida albicans, human erythrocytes, and Acholeplasma laidlawii was studied. The results sustain the observations made with lecithin-sterol liposomes. The distribution of double bonds in the membrane sterol nucleus appears to be of major importance in conferring polyene susceptibility; those sterols with the ergosterol nucleus are far more effective than those with a nucleus similar to cholesterol. Different polyenes vary in their membrane selectivity. The clinical implications of these observations are discussed.
摘要
研究了多烯抗生素对白色念珠菌、人红细胞和莱氏无胆甾原体的作用。结果支持了对卵磷脂 - 甾醇脂质体的观察结果。膜甾醇核中双键的分布在赋予多烯敏感性方面似乎至关重要；具有麦角甾醇核的甾醇比具有类似于胆固醇核的甾醇更有效。不同的多烯在其膜选择性方面存在差异。讨论了这些观察结果的临床意义。
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Antimicrob Agents Chemother. 1973 Sep;4(3):309-15. doi: 10.1128/AAC.4.3.309.
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Polyene antibiotic action on lecithin liposomes: effect of cholesterol and fatty acyl chains.多烯抗生素对卵磷脂脂质体的作用：胆固醇和脂肪酰链的影响
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