Berard C W, Cossman J, Jaffe E S
Br J Cancer. 1980 Jul;42(1):1-20. doi: 10.1038/bjc.1980.197.
Malignant lymphomas have traditionally been classified on solely morphological grounds. With new immunological and cytochemical techniques, it has been possible to characterize normal cells of the T-lymphocyte, B-lymphocyte, and monocyte-macrophage system. Application of these methodologies to malignant lymphomas has established their nature as neoplasms of the immune system. Within the B-lymphocyte system it is possible to identify subpopulations responsible for Burkitt's tumour, follicular (nodular) lymphomas, lymphocytic lymphomas of intermediate differentiation and well differentiated lymphocytic lymphomas. The T-lymphocyte system includes lymphoblastic lymphomas, mycosis fungoides, and Sezary's syndrome. Large-cell lymphomas are diverse, but the majority are tumours of transformed lymphocytes, usually of the B-lymphocyte system. The precise nature of the neoplastic cells of Hodgkin's disease (i.e., Reed-Sternberg cells and their mononuclear counterparts) has not yet been established. Despite previous suggestions of a B-lymphocyte or T-lymphocyte origin, recent studies with in vitro cultivation have strongly suggested derivation from the monocyte-macrophage system.
恶性淋巴瘤传统上仅根据形态学进行分类。随着新的免疫和细胞化学技术的出现，已经能够对T淋巴细胞、B淋巴细胞和单核细胞-巨噬细胞系统的正常细胞进行特征描述。将这些方法应用于恶性淋巴瘤已确定它们是免疫系统的肿瘤。在B淋巴细胞系统中，可以识别出与伯基特氏瘤、滤泡性（结节性）淋巴瘤、中度分化淋巴细胞淋巴瘤和高分化淋巴细胞淋巴瘤相关的亚群。T淋巴细胞系统包括淋巴母细胞淋巴瘤、蕈样肉芽肿和塞扎里综合征。大细胞淋巴瘤种类多样，但大多数是转化淋巴细胞的肿瘤，通常是B淋巴细胞系统的。霍奇金病肿瘤细胞（即里德-斯腾伯格细胞及其单核对应细胞）的确切性质尚未确定。尽管之前有关于B淋巴细胞或T淋巴细胞起源的说法，但最近的体外培养研究强烈表明其起源于单核细胞-巨噬细胞系统。
