眼部衣原体感染的免疫性。II. 豚鼠包涵体结膜炎感染抵抗力中被动转移血清抗体的研究。
Immunity to chlamydial infections of the eye. II. Studies of passively transferred serum antibody in resistance to infection with guinea pig inclusion conjunctivitis.
作者信息
Watson R R, Mull J D, MacDonald A B, Thompson S E, Bear S E
出版信息
Infect Immun. 1973 Apr;7(4):597-9. doi: 10.1128/iai.7.4.597-599.1973.
Conjunctival infection of guinea pigs by the chlamydial agent of guinea pig inclusion conjunctivitis confers immunity. However, the mechanism of resistance to this intracellular pathogen is not yet defined. In the study reported here, serum immunoglobulin was passively transferred with resultant titers in excess of those known to be associated with immunity. Nonetheless, when the passive transfer recipients were challenged, they acquired infection which was neither delayed nor attenuated. Eye secretion antibody titers appeared and increased only after 11 days of infection in both passive transfer recipients and control groups, suggesting but not proving de novo local synthesis of secretory antibody. This study suggests that cellular or secretory immune mechanisms may predominate in resistance to this infection.
豚鼠因感染豚鼠包涵体结膜炎的衣原体病原体而引发结膜感染，可产生免疫力。然而，针对这种细胞内病原体的抵抗机制尚未明确。在本文报道的研究中，血清免疫球蛋白被被动转移，其产生的滴度超过了已知与免疫相关的滴度。尽管如此，当被动转移接受者受到攻击时，他们仍感染了病原体，且感染既未延迟也未减轻。在被动转移接受者和对照组中，眼部分泌物抗体滴度仅在感染11天后才出现并升高，这表明但未证实分泌性抗体是重新在局部合成的。这项研究表明，细胞免疫或分泌免疫机制可能在抵抗这种感染中起主导作用。
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