Rank R G, Barron A L
Infect Immun. 1987 Sep;55(9):2317-9. doi: 10.1128/iai.55.9.2317-2319.1987.
Estradiol treatment of female guinea pigs was found to alter the course of genital, but not ocular, infection with the chlamydial agent of guinea pig inclusion conjunctivitis. Immunoglobulin G (IgG) and IgA responses in genital secretions of genitally infected animals were delayed by estradiol treatment, but neither response in the eye resulting from either ocular or genital infection was affected. However, the appearance of IgG in the genital tract after ocular infection was markedly inhibited in estradiol-treated guinea pigs.
研究发现,用雌二醇处理雌性豚鼠会改变豚鼠包涵体结膜炎衣原体病原体引起的生殖道感染病程,但不会改变眼部感染病程。雌二醇处理会延迟生殖道感染动物生殖道分泌物中的免疫球蛋白G(IgG)和IgA反应,但眼部或生殖道感染引起的眼部反应均未受影响。然而,在经雌二醇处理的豚鼠中,眼部感染后生殖道中IgG的出现受到明显抑制。