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雌二醇对衣原体眼部和生殖器感染中生殖器黏膜抗体反应的特定作用。

Specific effect of estradiol on the genital mucosal antibody response in chlamydial ocular and genital infections.

作者信息

Rank R G, Barron A L

出版信息

Infect Immun. 1987 Sep;55(9):2317-9. doi: 10.1128/iai.55.9.2317-2319.1987.

Abstract

Estradiol treatment of female guinea pigs was found to alter the course of genital, but not ocular, infection with the chlamydial agent of guinea pig inclusion conjunctivitis. Immunoglobulin G (IgG) and IgA responses in genital secretions of genitally infected animals were delayed by estradiol treatment, but neither response in the eye resulting from either ocular or genital infection was affected. However, the appearance of IgG in the genital tract after ocular infection was markedly inhibited in estradiol-treated guinea pigs.

摘要

研究发现,用雌二醇处理雌性豚鼠会改变豚鼠包涵体结膜炎衣原体病原体引起的生殖道感染病程,但不会改变眼部感染病程。雌二醇处理会延迟生殖道感染动物生殖道分泌物中的免疫球蛋白G(IgG)和IgA反应,但眼部或生殖道感染引起的眼部反应均未受影响。然而,在经雌二醇处理的豚鼠中,眼部感染后生殖道中IgG的出现受到明显抑制。

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本文引用的文献

6
Effects of various doses of estradiol on chlamydial genital infection in ovariectomized guinea pigs.
Sex Transm Dis. 1985 Jan-Mar;12(1):8-13. doi: 10.1097/00007435-198501000-00003.

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