Orenstein N S, Mull J D, Thompson S E
Infect Immun. 1973 Apr;7(4):600-3. doi: 10.1128/iai.7.4.600-603.1973.
Previous studies have shown that owl monkeys which have had a trachoma agent infection were subsequently highly resistant to challenge by both homologous and heterologous organisms. In the present study, passive transfer of owl monkey serum containing antitrachoma antibody from immune monkeys did not protect recipient monkeys from infectious challenge with homologous trachoma. Antibody was not detectable in eye secretions of the recipient monkeys until the intensity of infection was waning, suggesting but not proving that local antibody synthesis rather than simple transudation of serum antibody occurs.
先前的研究表明,曾感染过沙眼病原体的夜猴随后对同源和异源病原体的攻击具有高度抗性。在本研究中,将含有来自免疫夜猴的抗沙眼抗体的血清被动转移给受体夜猴,并不能保护受体夜猴免受同源沙眼感染的挑战。直到感染强度减弱时,才在受体夜猴的眼分泌物中检测到抗体,这表明(但未证实)是局部抗体合成而非血清抗体的简单渗出。