Aiuti F, Lacava V, Garofalo J A, D'Amelio R, D'Asero C
Clin Exp Immunol. 1973 Sep;15(1):43-52.
Peripheral blood lymphocytes of twenty normal controls and twelve patients with primary immunodeficiencies were examined for surface membrane Ig and receptors for C3 complement (B cell markers) and for spontaneous rosette formation with sheep erythrocytes (T cell markers). In patients with defects in T cell function no lymphocytes forming spontaneous rosettes were seen. In patients with B cell deficiency they were normal or increased. Lymphocytes with membrane immunoglobulins were normal in patients with T cell defect and absent in patients with severe agammaglobulinaemia. Lymphocytes with receptors for C3 complement were increased in patients with T defect and normal in patients with most other forms of immunodeficiency studied.
对20名正常对照者和12名原发性免疫缺陷患者的外周血淋巴细胞进行检测，以观察其表面膜免疫球蛋白和C3补体受体（B细胞标志物），以及与绵羊红细胞的自发玫瑰花结形成情况（T细胞标志物）。在T细胞功能缺陷的患者中，未观察到形成自发玫瑰花结的淋巴细胞。在B细胞缺陷的患者中，这些细胞数量正常或增加。有膜免疫球蛋白的淋巴细胞在T细胞缺陷患者中正常，而在严重无丙种球蛋白血症患者中缺失。有C3补体受体的淋巴细胞在T细胞缺陷患者中增加，而在研究的大多数其他形式免疫缺陷患者中正常。
