Strachan R G, Paleveda W J, Bergstrand S J, Nutt R F, Holly F W, Veber D F
J Med Chem. 1979 May;22(5):586-8. doi: 10.1021/jm00191a026.
Less than Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn, a proposed serum thymic factor, has been synthesized. The protected precursor, less than Glu-Ala-Lys(i-Noc)-ser(Bzl)-Gln-Gly-Gly-Ser(Bzl)-Asn, was prepared by a combination of solid phase and solution methods. The benzyl blocking groups were removed by HF and the i-Noc blocking group was removed by catalytic hydrogenation.
