Day A T, Golding J R, Lee P N, Butterworth A D
Br Med J. 1974 Feb 2;1(5900):180-3. doi: 10.1136/bmj.1.5900.180.
Eighty-five patients with rheumatoid disease were treated with penicillamine, and 69 completed more than one year's treatment. The main reason for discontinuing penicillamine in the 16 patients who withdrew was adverse reaction. The number of adverse reactions, however, declined when patients were given lower maintenance doses of penicillamine. In those who tolerated the drug the results of treatment were good. To prevent side effects the drug should be introduced gradually and maintenance doses should be the lowest which produce a satisfactory response. Urine should be monitored for protein and blood for changes in platelet and white cell counts at frequent intervals throughout treatment.
85例类风湿病患者接受了青霉胺治疗，其中69例完成了一年以上的治疗。16例停药患者停用青霉胺的主要原因是不良反应。然而，当给予患者较低维持剂量的青霉胺时，不良反应的数量有所下降。在耐受该药物的患者中，治疗效果良好。为预防副作用，应逐渐引入该药物，维持剂量应是产生满意反应的最低剂量。在整个治疗过程中，应定期监测尿液中的蛋白质和血液中的血小板及白细胞计数变化。
