Golding J R, Wilson J V, Day A T
Postgrad Med J. 1970 Oct;46(540):599-605. doi: 10.1136/pgmj.46.540.599.
Forty-five patients with severe rheumatoid arthritis were given D-penicillamine hydrochloride according to a fixed regimen for up to 2 years. The effects of treatment were observed both clinically and by the use of laboratory parameters. The results show that about 75% of patients exhibited objective improvement. Those with rheumatoid arthritis were found to do particularly well. The incidence, type and severity of side-effects are discussed.
45例重症类风湿关节炎患者按照固定方案服用盐酸青霉胺，疗程长达2年。通过临床观察和实验室指标对治疗效果进行了评估。结果显示，约75%的患者有客观改善。类风湿关节炎患者疗效尤为显著。文中讨论了副作用的发生率、类型及严重程度。
