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[在“宇宙-782”生物卫星飞行后动物器官中DNA合成的强度]

[Intensity of DNA synthesis in animal organs after a flight on the Kosmos-782 biosatellite].

作者信息

Guseĭnov F T, Egorov I A, Komolova G S, Tigranian R A

出版信息

Kosm Biol Aviakosm Med. 1979 Jul-Aug;13(4):30-3.

PMID:459398
Abstract

With respect to H3-thymidine incorporation the rate of DNA synthesis in the liver, spleen and thymus of rats was determined in flight and synchronous rats. Six hours post-flight the rate of H3-thymidine incorporation into the liver of flight rats did not differ from the normal (vivarium controls) and was 50% higher than in the synchronous rats. In the spleen and thymus of flight animals this parameter was 60 and 33% below the norm. Similar but less pronounced changes in the spleen were found in the synchronous rats. Twenty-five days postflight the rate of DNA synthesis in lymph organs recovered completely and tended to increase, whereas in the liver it remained significantly below the norm.

摘要

关于³H-胸腺嘧啶核苷掺入,在飞行大鼠和同步对照大鼠中测定了肝脏、脾脏和胸腺中DNA合成的速率。飞行后6小时,飞行大鼠肝脏中³H-胸腺嘧啶核苷的掺入速率与正常(饲养对照)大鼠无差异,且比同步对照大鼠高50%。在飞行动物的脾脏和胸腺中,该参数比正常水平低60%和33%。在同步对照大鼠的脾脏中也发现了类似但不太明显的变化。飞行后25天,淋巴器官中DNA合成速率完全恢复并趋于增加,而肝脏中的DNA合成速率仍显著低于正常水平。

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