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[长期太空飞行对大鼠不同组织和器官中蛋白质生物合成的影响]

[Effect of long-term space flight on protein biosynthesis in different rat tissues and organs].

作者信息

Rapoport E A, Goncharova L A, Morenkova S A, Kazarian V A

出版信息

Kosm Biol Aviakosm Med. 1977 Jul-Aug;11(4):20-4.

PMID:904280
Abstract

Protein synthesis in the heart, lungs, liver, pancreas, thymus, kidneys, skeletal muscles and testes of the 22-day Cosmos-605 flight and synchronous rats was studied with the aif of 14C-amino acid incorporation. On the 2nd postflight day both flight and synchronous rats showed an increased synthesis of heart sarcoplasmatic proteins. On the 26th postflight day the rate of incorporation was normal. On the 2nd and 26th days the synthesis of myofibrillar proteins in the m. quadriceps femoris was inhibited in flight animals postflight day the rate of incorporation was normal. On the 2nd and 26th days the syn-only. On the 2nd and 26th days the liver of the flight and synchronous rats showed qualitatively similar changes in protein metabolism of subcellular structures. No changes in the protein synthesis of other organs tested were detected.

摘要

利用¹⁴C-氨基酸掺入法研究了22日龄的“宇宙-605”号飞行大鼠和同步对照大鼠心脏、肺、肝脏、胰腺、胸腺、肾脏、骨骼肌和睾丸中的蛋白质合成情况。在飞行后第2天,飞行大鼠和同步对照大鼠心脏肌浆蛋白的合成均增加。在飞行后第26天,掺入率正常。在飞行后第2天和第26天,飞行大鼠股四头肌肌原纤维蛋白的合成受到抑制,而同步对照大鼠仅在飞行后第2天受到抑制。在飞行后第2天和第26天,飞行大鼠和同步对照大鼠肝脏亚细胞结构的蛋白质代谢呈现出定性相似的变化。未检测到其他受试器官蛋白质合成的变化。

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