两性霉素B增强抗生素的抗真菌作用。
Potentiation of the antifungal effects of antibiotics by amphotericin B.
作者信息
Kwan C N, Medoff G, Kobayashi G S, Schlessinger D, Raskas H J
出版信息
Antimicrob Agents Chemother. 1972 Aug;2(2):61-5. doi: 10.1128/AAC.2.2.61.
Abstract
Amphotericin B was found to potentiate the antifungal effects of mycophenolic acid glucuronide, tetracycline, and actinomycin D by increasing the penetration of these antibiotics through the fungal cytoplasmic membrane. Because the fungi were over 100 times more susceptible than animal cells to these effects of amphotericin B, these observations might have clinical application.
摘要
两性霉素B被发现可增强麦考酚酸葡糖苷酸、四环素和放线菌素D的抗真菌作用，其机制是增加这些抗生素透过真菌细胞质膜的能力。由于真菌对两性霉素B的这些作用的敏感性比动物细胞高100倍以上，这些观察结果可能具有临床应用价值。
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本文引用的文献
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Potentiation of rifampicin and 5-fluorocytosine as antifungal antibiotics by amphotericin B (yeast-membrane permeability-ribosomal RNA-eukaryotic cell-synergism).两性霉素B增强利福平与5-氟胞嘧啶作为抗真菌抗生素的作用（酵母细胞膜通透性-核糖体RNA-真核细胞-协同作用）
Proc Natl Acad Sci U S A. 1972 Jan;69(1):196-9. doi: 10.1073/pnas.69.1.196.
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