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两性霉素B增强抗生素的抗真菌作用。

Potentiation of the antifungal effects of antibiotics by amphotericin B.

作者信息

Kwan C N, Medoff G, Kobayashi G S, Schlessinger D, Raskas H J

出版信息

Antimicrob Agents Chemother. 1972 Aug;2(2):61-5. doi: 10.1128/AAC.2.2.61.

DOI:10.1128/AAC.2.2.61
PMID:4597115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC444268/
Abstract

Amphotericin B was found to potentiate the antifungal effects of mycophenolic acid glucuronide, tetracycline, and actinomycin D by increasing the penetration of these antibiotics through the fungal cytoplasmic membrane. Because the fungi were over 100 times more susceptible than animal cells to these effects of amphotericin B, these observations might have clinical application.

摘要

两性霉素B被发现可增强麦考酚酸葡糖苷酸、四环素和放线菌素D的抗真菌作用，其机制是增加这些抗生素透过真菌细胞质膜的能力。由于真菌对两性霉素B的这些作用的敏感性比动物细胞高100倍以上，这些观察结果可能具有临床应用价值。

相似文献

1
Potentiation of the antifungal effects of antibiotics by amphotericin B.两性霉素B增强抗生素的抗真菌作用。
Antimicrob Agents Chemother. 1972 Aug;2(2):61-5. doi: 10.1128/AAC.2.2.61.
2
Potentiation of rifampicin and 5-fluorocytosine as antifungal antibiotics by amphotericin B (yeast-membrane permeability-ribosomal RNA-eukaryotic cell-synergism).两性霉素B增强利福平与5-氟胞嘧啶作为抗真菌抗生素的作用（酵母细胞膜通透性-核糖体RNA-真核细胞-协同作用）
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本文引用的文献

1
The inhibition of nucleic acid synthesis by mycophenolic acid.霉酚酸对核酸合成的抑制作用。
Biochem J. 1969 Jul;113(3):515-24. doi: 10.1042/bj1130515.
2
Possible in situ activation of mycophenolic acid by beta-glucuronidase.β-葡萄糖醛酸酶可能使霉酚酸发生原位激活。
Cancer Res. 1971 Apr;31(4):477-8.
3
Macromolecule synthesis in temperature-sensitive mutants of yeast.酵母温度敏感突变体中的大分子合成
J Bacteriol. 1967 May;93(5):1662-70. doi: 10.1128/jb.93.5.1662-1670.1967.
4
Synergistic action of amphotericin B and 5-fluorocytosine against yeast-like organisms.两性霉素B与5-氟胞嘧啶对酵母样菌的协同作用。
Proc Soc Exp Biol Med. 1971 Nov;138(2):571-4. doi: 10.3181/00379727-138-35943.
5
Inhibitors of protein synthesis by ribosomes of the 80-S type.80-S型核糖体蛋白质合成抑制剂。
Biochim Biophys Acta. 1971 Dec 16;254(2):316-30. doi: 10.1016/0005-2787(71)90840-9.
6
Antibiotic interaction with model membranes.抗生素与模型膜的相互作用。
Annu Rev Pharmacol. 1970;10:119-42. doi: 10.1146/annurev.pa.10.040170.001003.
7
Potentiation of rifampicin and 5-fluorocytosine as antifungal antibiotics by amphotericin B (yeast-membrane permeability-ribosomal RNA-eukaryotic cell-synergism).两性霉素B增强利福平与5-氟胞嘧啶作为抗真菌抗生素的作用（酵母细胞膜通透性-核糖体RNA-真核细胞-协同作用）
Proc Natl Acad Sci U S A. 1972 Jan;69(1):196-9. doi: 10.1073/pnas.69.1.196.