Hamid J, Sayeed A, McFarlane H
Br J Exp Pathol. 1974 Feb;55(1):94-100.
The drug o,p′-DDD diminished the body weight as well as the weights of the thymus, spleen and adrenals of rats. There was minimal fatty infiltration of the liver. In well-nourished rats o,p′-DDD produced atrophy of both the adrenal cortex and the thymolymphatic organs, but no changes could be detected in kidneys, heart and lungs. The numbers of plaque-forming cells (PFC) and rosette-forming cells (RFC) in the spleen and thymus of the o,p′-DDD treated rats were lower than the controls. The effect of o,p′-DDD was greatest on the adrenal cortex of the malnourished rats with a diminution of plasma corticosteroid concentration and less impairment of the immune response. The numbers of PFC and RFC in the spleen and thymus of the o,p′-DDD-treated malnourished rats were almost equal to that of their controls. It was interesting to observe that o,p′-DDD seemed to affect PFC more adversely than RFC. In comparison to the controls, thymocytes and spleen cells of the o,p′-DDD-treated rats responded better to phytohaemagglutinin (PHA) than to pokeweed mitogen (PWM).
药物邻对滴滴滴（o,p′-DDD）可使大鼠体重减轻，同时使胸腺、脾脏和肾上腺重量减轻。肝脏仅有轻微脂肪浸润。在营养良好的大鼠中，邻对滴滴滴会导致肾上腺皮质和胸腺淋巴器官萎缩，但在肾脏、心脏和肺部未检测到变化。经邻对滴滴滴处理的大鼠脾脏和胸腺中形成斑块细胞（PFC）和形成玫瑰花结细胞（RFC）的数量低于对照组。邻对滴滴滴对营养不良大鼠的肾上腺皮质影响最大，可降低血浆皮质类固醇浓度，且对免疫反应的损害较小。经邻对滴滴滴处理的营养不良大鼠脾脏和胸腺中PFC和RFC的数量几乎与对照组相等。有趣的是，观察到邻对滴滴滴对PFC的不利影响似乎比对RFC更大。与对照组相比，经邻对滴滴滴处理的大鼠胸腺细胞和脾细胞对植物血凝素（PHA）的反应比对商陆有丝分裂原（PWM）的反应更好。
