[线粒体和微粒体电子传递的变化受邻，对'-二氯二苯二氯乙烷的影响]

[Changes in mitochondrial and microsomal electron transport as affected by o,p'-dichlorodiphenyldichloroethane].

作者信息

Komissarenko V P, Mikosha A S, Chelnakova I S

出版信息

Ukr Biokhim Zh (1978). 1981 Nov-Dec;53(6):74-7.

Abstract

The paper deals with the influence of 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2.2-dichloroethane (o,p'-DDD, chloditane) on NADPH-dependent reduction of cytochrome c, ferricyanide, 2,6-dichlorophenolindophenol and neotetrazolium; 156 and 312 mumol o,p'-DDD was added to the dog adrenal mitochondrial and microsomal suspension. Ferricyanide reduction decreased and neotetrazolium reduction increased under the influence of o,p'-DDD. Reduction of cytochrome c was inhibited in microsomal fraction and activated in mitochondrial one. o,p'-DDD exerted no influence on 2,6-dichlorophenolindophenol reduction in the adrenal subcellular fractions. The possible mechanisms of o,p'-DDD action on the electron transport system were discussed.

摘要

本文探讨了1-（邻氯苯基）-1-（对氯苯基）-2,2-二氯乙烷（邻，对'-滴滴滴，氯地孕酮）对细胞色素c、铁氰化物、2,6-二氯酚靛酚和新四氮唑NADPH依赖性还原的影响；向犬肾上腺线粒体和微粒体悬浮液中加入156和312μmol邻，对'-滴滴滴。在邻，对'-滴滴滴的影响下，铁氰化物还原减少，新四氮唑还原增加。微粒体部分中细胞色素c的还原受到抑制，而线粒体部分中细胞色素c的还原被激活。邻，对'-滴滴滴对肾上腺亚细胞部分中2,6-二氯酚靛酚的还原没有影响。讨论了邻，对'-滴滴滴对电子传递系统作用的可能机制。

相似文献

1

[Changes in mitochondrial and microsomal electron transport as affected by o,p'-dichlorodiphenyldichloroethane].[线粒体和微粒体电子传递的变化受邻，对'-二氯二苯二氯乙烷的影响]

Ukr Biokhim Zh (1978). 1981 Nov-Dec;53(6):74-7.

2

Treatment with o,p'-DDD (mitotane) decreased cytochrome P-450, heme, and microsomal protein content in the dog adrenal cortex in vivo.

Res Commun Chem Pathol Pharmacol. 1976 Jan;13(1):83-92.

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Effect of o,p'-dichlorodiphenyldichloroethane on glutathione reductase activity and content of SH groups in the dog adrenals.邻对二氯二苯二氯乙烷对犬肾上腺中谷胱甘肽还原酶活性及巯基含量的影响。

Bull Exp Biol Med. 1975 Jan;77(7):761-3. doi: 10.1007/BF00799312.

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Biokhimiia. 1993 Nov;58(11):1761-70.

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