Lim R, Mitsunobu K
Science. 1974 Jul 5;185(4145):63-6. doi: 10.1126/science.185.4145.63.
One type of elmbryonic rat brain cell having an epithelioid morphology in the monolayer culture can be transformed by brain extract into cells having extensive processes resembling mature astrocytes. The transforming factor is a protein with a molecular weight of 350,000. A partially purified sample showed that it is active at a concentration as low as 1 x 10(-8)M. The transforming actvity is high in adult brains but low in embryonic brains and tumors of the nervous systems.
在单层培养中呈现上皮样形态的一种胚胎大鼠脑细胞，可被脑提取物转化为具有类似于成熟星形胶质细胞的广泛突起的细胞。转化因子是一种分子量为350,000的蛋白质。部分纯化的样品表明，其在低至1×10⁻⁸M的浓度下仍具有活性。转化活性在成体脑中较高，但在胚胎脑和神经系统肿瘤中较低。
