Lim R, Miller J F
Experientia. 1985 Mar 15;41(3):412-5. doi: 10.1007/BF02004534.
Newborn rats were injured with a puncture wound in one cerebral hemisphere. Experimental animals were treated with three i.p. injections of Glia Maturation Factor (GMF) at daily intervals starting from the time of injury, whereas control littermates were treated with equivalent amounts of bovine serum albumin. At 25 days old the size of the cerebral cortex at the plane of injury was measured on representative brain sections. In control rats the injured side was 18% smaller than the normal side whereas in GMF-treated animals the difference was only 1%. The results suggest a possible regulatory role of GMF in promoting tissue recovery from brain damage.
新生大鼠的一个大脑半球受到穿刺伤。从受伤时起，对实验动物每隔一天进行三次腹腔注射胶质细胞成熟因子（GMF），而对同窝对照动物注射等量的牛血清白蛋白。在25日龄时，在代表性脑切片上测量损伤平面处大脑皮层的大小。在对照大鼠中，受伤侧比正常侧小18%，而在接受GMF治疗的动物中，差异仅为1%。结果表明GMF在促进脑损伤组织恢复方面可能具有调节作用。
