Dornan J, Reynolds W J
Can Med Assoc J. 1974 Jun 22;110(12):1370-2.
A double-blind crossover study of ibuprofen and acetylsalicylic acid was carried out in 27 patients with rheumatoid arthritis. Patients were evaluated by joint counts, grip-strength determination, erythrocyte sedimentation rate, and number of acetaminophen tablets required in addition to the test drug, as well as by various biochemical measurements. In the doses used ibuprofen and acetylsalicylic acid appeared comparable in anti-inflammatory effect, but statistically fewer side effects were observed during administration of ibuprofen.
对27例类风湿性关节炎患者进行了布洛芬和乙酰水杨酸的双盲交叉研究。通过关节计数、握力测定、红细胞沉降率、除试验药物外所需对乙酰氨基酚片的数量以及各种生化测量对患者进行评估。在所使用的剂量下,布洛芬和乙酰水杨酸的抗炎效果相当,但在服用布洛芬期间观察到的副作用在统计学上较少。