与致癌物N-甲基-N-亚硝基脲反应的DNA中O6-甲基鸟嘌呤和3-甲基腺嘌呤的酶促释放。
The enzymatic release of O6-methylguanine and 3-methyladenine from DNA reacted with the carcinogen N-methyl-N-nitrosourea.
作者信息
Kirtikar D M, Goldthwait D A
出版信息
Proc Natl Acad Sci U S A. 1974 May;71(5):2022-6. doi: 10.1073/pnas.71.5.2022.
Abstract
Endonuclease II (deoxyribonucleate oligonucleotidohydrolase, EC 3.1.4.30) of Escherichia coli has been shown to break phosphodiester bonds in alkylated DNA and depurinated DNA. The hypothesis that depurination is a step in the mechanism of the reaction with alkylated DNA is supported by in vitro experiments with DNA reacted with N-methyl-N-nitrosourea. Endonuclease II releases O(6)-methylguanine and 3-methyladenine, but not 7-methylguanine, from DNA that has been methylated by the carcinogen N-methyl-N-nitrosourea.
摘要
大肠杆菌的核酸内切酶II（脱氧核糖核酸寡核苷酸水解酶，EC 3.1.4.30）已被证明能断裂烷基化DNA和脱嘌呤DNA中的磷酸二酯键。脱嘌呤是与烷基化DNA反应机制中的一个步骤这一假说，得到了DNA与N-甲基-N-亚硝基脲反应的体外实验的支持。核酸内切酶II从被致癌物N-甲基-N-亚硝基脲甲基化的DNA中释放出O(6)-甲基鸟嘌呤和3-甲基腺嘌呤，但不释放7-甲基鸟嘌呤。
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