细胞骨架-质膜复合体是否参与晶状体蛋白的生物合成？

Is the cytoskeleton-plasma membrane complex involved in lens protein biosynthesis?

作者信息

Bloemendal H, Benedetti E L, Ramaekers F C, Dunia I, Kibbelaar M A, Vermorken A J

出版信息

Mol Biol Rep. 1979 May 31;5(1-2):99-103. doi: 10.1007/BF00777495.

Abstract

Calf lens fiber cells contain a population of polyribosomes that direct, at least in vitro, the synthesis of a specific plasma membrane protein MP26. This protein may serve as a marker in terminal differentiation, since it is absent in the lens epithelium but appears in lens fiber plasma membranes. The MP26 manufacturing polyribosomes are found to be associated with a structural complex in which also the cytoskeleton and plasma membranes participate. They can be released from the complex by treatment with DNAse I. This result presumably reflects the involvement of actin in the linkage of the MP26 synthesizing polyribosomes to the cytoskeleton-membrane complex.

摘要

小牛晶状体纤维细胞含有一群多核糖体，至少在体外，这些多核糖体指导一种特定的质膜蛋白MP26的合成。这种蛋白可能作为终末分化的标志物，因为它在晶状体上皮细胞中不存在，但出现在晶状体纤维质膜中。发现制造MP26的多核糖体与一种结构复合体相关，细胞骨架和质膜也参与其中。用DNA酶I处理可使它们从复合体中释放出来。这一结果大概反映了肌动蛋白在将合成MP26的多核糖体与细胞骨架-膜复合体连接中的作用。