Guentzel M N, Berry L J
Infect Immun. 1974 Jul;10(1):167-72. doi: 10.1128/iai.10.1.167-172.1974.
The susceptibility of suckling mice to oral infection with several different Vibrio cholerae was determined. Mice up to 10 days of age were uniformly susceptible to oral infection with 10(8) colony-forming units of virulent organisms. Age-dependent resistance occurred thereafter to a maximum at about 15 days of age. The efficacy of selected vaccines was compared by oral challenge of 8-day-old, passively immunized CFW mice. An Ogawa-derived ribosomal antigen was found to be superior to a commercial whole-cell vaccine or to purified cholera enterotoxin. The ribosomal antigen was 50- to 100-fold more protective than the other vaccines on a weight basis against otherwise lethal challenge with Ogawa, Inaba, or El Tor Ogawa serotypes.
测定了乳鼠对几种不同霍乱弧菌口服感染的易感性。10日龄以内的小鼠对口服10⁸个毒力菌株集落形成单位的感染均易感。此后出现年龄依赖性抗性，约在15日龄时达到最大值。通过对8日龄、被动免疫的CFW小鼠进行口服攻毒，比较了所选疫苗的效力。发现源自小川型的核糖体抗原有优于市售全细胞疫苗或纯化霍乱肠毒素。按重量计算，核糖体抗原对小川型、稻叶型或埃尔托小川型血清型的致死性攻毒的保护作用比其他疫苗高50至100倍。
