通过母体免疫保护乳鼠免受实验性霍乱：全细胞、核糖体衍生和肠毒素免疫原的疗效比较。
Protection of suckling mice from experimental cholera by maternal immunization: comparison of the efficacy of whole-cell, ribosomal-derived, and enterotoxin immunogens.
作者信息
Guentzel M N, Berry L J
出版信息
Infect Immun. 1974 Jul;10(1):167-72. doi: 10.1128/iai.10.1.167-172.1974.
Abstract
The susceptibility of suckling mice to oral infection with several different Vibrio cholerae was determined. Mice up to 10 days of age were uniformly susceptible to oral infection with 10(8) colony-forming units of virulent organisms. Age-dependent resistance occurred thereafter to a maximum at about 15 days of age. The efficacy of selected vaccines was compared by oral challenge of 8-day-old, passively immunized CFW mice. An Ogawa-derived ribosomal antigen was found to be superior to a commercial whole-cell vaccine or to purified cholera enterotoxin. The ribosomal antigen was 50- to 100-fold more protective than the other vaccines on a weight basis against otherwise lethal challenge with Ogawa, Inaba, or El Tor Ogawa serotypes.
摘要
测定了乳鼠对几种不同霍乱弧菌口服感染的易感性。10日龄以内的小鼠对口服10⁸个毒力菌株集落形成单位的感染均易感。此后出现年龄依赖性抗性，约在15日龄时达到最大值。通过对8日龄、被动免疫的CFW小鼠进行口服攻毒，比较了所选疫苗的效力。发现源自小川型的核糖体抗原有优于市售全细胞疫苗或纯化霍乱肠毒素。按重量计算，核糖体抗原对小川型、稻叶型或埃尔托小川型血清型的致死性攻毒的保护作用比其他疫苗高50至100倍。
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本文引用的文献
1
Mechanism of Action of Intestinal Antibody in Experimental Cholera II. Antibody-Mediated Antibacterial Reaction at the Mucosal Surface.肠抗体在实验性霍乱中的作用机制 II. 黏膜表面的抗体介导的抗菌反应。
Infect Immun. 1970 Nov;2(5):556-62. doi: 10.1128/iai.2.5.556-562.1970.
2
Immunogenicity of Ribonucleic Acid Preparations Obtained from Salmonella typhimurium.从鼠伤寒沙门氏菌中获得的核糖核酸制剂的免疫原性。
Infect Immun. 1970 Jun;1(6):574-82. doi: 10.1128/iai.1.6.574-582.1970.
3
Antitoxic immunity in experimental cholera: observations with purified antigens and the rat foot edema model.实验性霍乱的抗毒免疫：用纯化抗原和大鼠足跖肿胀模型的观察。
Infect Immun. 1970 May;1(5):468-73. doi: 10.1128/iai.1.5.468-473.1970.
4
Antitoxic immunity in experimental cholera: observations with purified antigens and the ligated ileal loop model.实验性霍乱的抗毒免疫：用纯化抗原和结扎回肠袢模型的观察。
Infect Immun. 1970 May;1(5):464-7. doi: 10.1128/iai.1.5.464-467.1970.
5
IMMUNOGENIC ACTIVITY OF A RIBOSOMAL FRACTION OBTAINED FROM MYCOBACTERIUM TUBERCULOSIS.从结核分枝杆菌获得的核糖体组分的免疫原活性
J Bacteriol. 1965 May;89(5):1291-8. doi: 10.1128/jb.89.5.1291-1298.1965.
6
Experimental cholera in infant mice: protective effects of antibody.幼鼠实验性霍乱：抗体的保护作用
J Infect Dis. 1972 May;125(5):480-5. doi: 10.1093/infdis/125.5.480.
7
Production of highly purified choleragen and choleragenoid.高纯度霍乱毒素和类霍乱毒素的生产。
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8
Effect of trypsin and ribonuclease on the immunogenic activity of ribosomes and ribonucleic acid isolated from Mycobacterium tuberculosis.胰蛋白酶和核糖核酸酶对从结核分枝杆菌分离出的核糖体及核糖核酸免疫原活性的影响。
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9
Preparation of highly immunogenic ribosomal fractions of Mycobacterium tuberculosis by use of sodium dodecyl sulfate.使用十二烷基硫酸钠制备结核分枝杆菌的高免疫原性核糖体组分
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10
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