Sinha V B, Bhaskaran K
Bull World Health Organ. 1973;49(6):605-13.
The protection conferred by parenteral cholera vaccines and cholera toxoid was determined in the rabbit ileal loop model of experimental cholera. Vibrio cholerae strains belonging to two different serotypes were employed, for immunization and challenge, to differentiate antibacterial and antitoxic immunity patterns. It was found that vaccines were protective but cholera toxoid was not, although serum antitoxin levels were high after administration of the latter. Antibacterial immunity was strictly serotype-specific, with evidence of cross-protection only between Ogawa and Inaba subtypes of serotype 1. Bivalent serotype 1 vaccines conferred protection against homologous challenge strains but immunity to Inaba infection was of shorter duration than immunity to Ogawa infection.
在实验性霍乱的兔回肠袢模型中确定了肠道外霍乱疫苗和霍乱类毒素所提供的保护作用。使用属于两种不同血清型的霍乱弧菌菌株进行免疫和攻击，以区分抗菌和抗毒素免疫模式。结果发现，疫苗具有保护作用，但霍乱类毒素没有，尽管在给予后者后血清抗毒素水平很高。抗菌免疫具有严格的血清型特异性，仅在血清型1的小川型和稻叶型亚型之间有交叉保护的证据。二价血清型1疫苗对同源攻击菌株具有保护作用，但对稻叶型感染的免疫持续时间比对小川型感染的免疫持续时间短。
