Ries K M, Cobbs C G, Gillenwater J Y, Levison M E, Mandell G L, Sande M A, Kaye D
Antimicrob Agents Chemother. 1973 Dec;4(6):593-6. doi: 10.1128/AAC.4.6.593.
Carbenicillin indanyl sodium, ampicillin, or cephalexin was administered orally to 61 patients with urinary tract infections. Assignment of drug was made by a computer-generated, randomized plan in a double-blind fashion. The rates of cure 4 weeks after therapy were 50, 42, and 50% for patients treated with carbenicillin, ampicillin, and cephalexin, respectively. Failure of therapy was correlated with chronicity of infection and sensitivity of the microorganism to the antibiotic used. Thirty-nine percent of the patients developed side effects, but there were no significant differences in side effects among the three antibiotics. This double-blind study demonstrates that carbenicillin indanyl sodium is as effective as ampicillin and cephalexin in treatment of urinary tract infections.
对61例尿路感染患者口服羧苄青霉素茚满酯钠、氨苄青霉素或头孢氨苄。药物分配采用计算机生成的随机方案，以双盲方式进行。治疗4周后的治愈率分别为：羧苄青霉素治疗组50%、氨苄青霉素治疗组42%、头孢氨苄治疗组50%。治疗失败与感染的慢性化以及微生物对所用抗生素的敏感性相关。39%的患者出现了副作用，但三种抗生素之间的副作用无显著差异。这项双盲研究表明，羧苄青霉素茚满酯钠在治疗尿路感染方面与氨苄青霉素和头孢氨苄同样有效。
