头孢氨苄与氨苄西林治疗泌尿系统感染的双盲对照试验
Comparative double-blind trial of cephalexin and ampicillin in treatment of urinary infections.
作者信息
Davies J A, Strangeways J E, Mitchell R G, Beilin L J, Ledingham J G, Holt J M
出版信息
Br Med J. 1971 Jul 24;3(5768):215-7. doi: 10.1136/bmj.3.5768.215.
Cephalexin was compared with ampicillin in the treatment of urinary tract infections by a random double-blind technique. Both drugs were found to be equally effective. In 21 out of 31 patients treated with cephalexin and in 20 out of 31 treated with ampicillin the urine was sterile three weeks after starting therapy. The bacteriological findings at one and eight weeks were also similar in both groups. No serious adverse reactions were attributable to cephalexin, which seemed to be tolerated rather better than ampicillin.
采用随机双盲技术比较了头孢氨苄与氨苄西林治疗尿路感染的疗效。结果发现两种药物同样有效。在接受头孢氨苄治疗的31例患者中，有21例在开始治疗三周后尿液无菌；在接受氨苄西林治疗的31例患者中，有20例在开始治疗三周后尿液无菌。两组在治疗1周和8周时的细菌学检查结果也相似。未发现头孢氨苄引起严重不良反应，而且其耐受性似乎比氨苄西林更好。
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