Wilkinson P J, Reeves D S, Wise R, Allen J T
Br Med J. 1975 May 3;2(5965):250-2. doi: 10.1136/bmj.2.5965.250.
Blood and urine levels of carbenicillin were measured in 10 healthy volunteers and four patients with renal failure after single and multiple oral dose of carfecillin. Urinary levels after 1000-mg doses in healthy subjects were considered sufficient for treatment of Pseudomonas aeruginosa urinary infections, but the serum levels were too low for chemotherapy of systemic infections with this organism even in severe renal failure. Urinary infections were treated in 35 inpatients with a seven-day course of carfecillin. The infection was eradicated in 21 cases (60%). In 12 cases the pathogen was Ps. aeruginosa, which was eradicated from eight patients (67%). Many patients had severe urinary tract disease. Side effects were virtually absent.
在10名健康志愿者和4名肾衰竭患者单次及多次口服羧苄青霉素后，测定了他们血液和尿液中羧苄青霉素的水平。健康受试者服用1000毫克剂量后的尿液水平被认为足以治疗铜绿假单胞菌尿路感染，但即使在严重肾衰竭的情况下，血清水平对于该菌引起的全身感染化疗来说也过低。35名住院患者接受了为期7天的羧苄青霉素治疗尿路感染。21例（60%）感染得到根除。在12例病例中，病原体为铜绿假单胞菌，其中8例（67%）患者的该菌被根除。许多患者患有严重的泌尿系统疾病。几乎没有出现副作用。
