Wheeler M H, Prescott R J, Forrest A P
Br J Surg. 1974 Aug;61(8):605-10. doi: 10.1002/bjs.1800610805.
In 6 dogs with innervated antral pouches (3 with vagally innervated fundic pouches and 3 with vagally denervated fundic pouches) gastric secretion was stimulated by a range of submaximal doses of pentagastrin, each infused intravenously for a period of 6 hours. During the three consecutive 2-hour collection periods of each test the antral pouch was perfused with isotonic saline of pH 7 0, 1.0 and 7.0 respectively at a rate of I ml/min. Neither acid nor pepsin secretion was inhibited by antral acidification. When the antral perfusion rate was increased to 3 ml/min there was still no inhibition of acid secretion from either type of fundic pouch. In each dog the acid response of the fundic pouch to perfusion of the innervated antral pouch with 0–5 per cent acetylcholine was significantly reduced when the pH of the perfusate was lowered from 7.0 to 1.0. The results provide no support for the existence of either an antral inhibitory hormone or inhibitory neural reflex active against pentagastrin-stimulated gastric secretion in the dog. It would seem that antral inhibition of gastric secretion is the result of a diminished release or formation of endogenous gastrin.
在6只具有神经支配的胃窦袋的狗（3只具有迷走神经支配的胃底袋，3只具有迷走神经去支配的胃底袋）中，通过一系列次最大剂量的五肽胃泌素刺激胃分泌，每次静脉输注6小时。在每次试验连续的三个2小时收集期内，胃窦袋分别以1毫升/分钟的速率用pH值为7.0、1.0和7.0的等渗盐水灌注。胃窦酸化既不抑制酸分泌也不抑制胃蛋白酶分泌。当胃窦灌注速率增加到3毫升/分钟时，两种类型的胃底袋的酸分泌仍未受到抑制。在每只狗中，当灌注液的pH值从7.0降至1.0时，胃底袋对用0 - 5%乙酰胆碱灌注有神经支配的胃窦袋的酸反应显著降低。这些结果不支持狗体内存在对五肽胃泌素刺激的胃分泌起作用的胃窦抑制激素或抑制性神经反射。似乎胃窦对胃分泌的抑制是内源性胃泌素释放或形成减少的结果。
