酿酒酵母中尿囊素降解相关基因的聚类
Clustering of the genes for allantoin degradation in Saccharomyces cerevisiae.
作者信息
Lawther R P, Riemer E, Chojnacki B, Cooper T G
出版信息
J Bacteriol. 1974 Aug;119(2):461-8. doi: 10.1128/jb.119.2.461-468.1974.
Abstract
We have shown that allantoin degradation in Saccharomyces cerevisiae proceeds exclusively through the intermediate formation of allantoic acid, urea, and allophanic acid. The number of reactions between allantoic acid and urea, however, remains obscure owing to our inability to isolate a mutant defective in ureidoglycolate hydrolase. Structural genes for the enzymes, allantoinase (dal1) and allantoicase (dal2) are located on chromosome IX promixal to the centromere in the order dal1-dal2-lysl.
摘要
我们已经表明，酿酒酵母中的尿囊素降解完全通过尿囊酸、尿素和脲基甲酸的中间形成过程进行。然而，由于我们无法分离出脲基乙醇酸水解酶缺陷的突变体，尿囊酸和尿素之间的反应数量仍然不清楚。尿囊素酶（dal1）和尿囊酸酶（dal2）的结构基因位于第九条染色体上，靠近着丝粒，顺序为dal1-dal2-lysl。
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