草尿酸：酿酒酵母中尿囊素降解酶的一种不可代谢诱导剂。
Oxaluric acid: a non-metabolizable inducer of the allantoin degradative enzymes in Saccharomyces cerevisiae.
作者信息
Sumrada R, Cooper T G
出版信息
J Bacteriol. 1974 Mar;117(3):1240-7. doi: 10.1128/jb.117.3.1240-1247.1974.
Abstract
Saccharomyces cerevisiae degrades allantoin in five steps to ammonia, CO(2), and glyoxylate. Previously we demonstrated that allophanic acid, the last intermediate of the pathway, was required for induction of all five degradative enzymes. The data presented here indicate that oxaluric acid, an allophanate analogue, is capable of serving as a non-metabolizable inducer. Oxaluric acid brings about a high level of induction even in strains lacking urea carboxylase. Induction observed with parabanic acid was found to result from its spontaneous breakdown to oxaluric acid.
摘要
酿酒酵母通过五步反应将尿囊素降解为氨、二氧化碳和乙醛酸。此前我们证明，该途径的最后一个中间体脲基甲酸是诱导所有五种降解酶所必需的。此处给出的数据表明，脲基甲酸类似物草尿酸能够作为一种不可代谢的诱导剂。即使在缺乏尿素羧化酶的菌株中，草尿酸也能引起高水平的诱导。发现用乙内酰脲观察到的诱导是由于其自发分解为草尿酸所致。
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Induction of the allantoin degradative enzymes in Saccharomyces cerevisiae by the last intermediate of the pathway.通过该途径的最后中间体诱导酿酒酵母中的尿囊素降解酶。
Proc Natl Acad Sci U S A. 1973 Aug;70(8):2340-4. doi: 10.1073/pnas.70.8.2340.
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The induction of urea carboxylase and allophanate hydrolase in Saccharomyces cerevisiae.
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Induction of the allantoin degradative enzymes by allophanic acid, the last intermediate of the pathway.
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