预免疫后粒细胞-巨噬细胞系统对细菌抗原的反应性降低。
Depressed responses of the granulocyte-macrophage system to bacterial antigens following preimmunization.
作者信息
Metcalf D
出版信息
Immunology. 1974 Jun;26(6):1115-25.
Abstract
Injection of C57B1 mice with endotoxin or other bacterial antigens normally produces (i) a rise in the serum level of a factor that stimulates granulocyte and macrophage colony formation and (ii) a rise in the numbers of granulocyte and macrophage progenitors in the blood. Preinjection of the mice with polymerized flagellins of species specifically depressed both types of response. After a single injection of flagellin, depressed responsiveness began within 24 hr, persisted for several months and could be passively transferred to normal mice by injection of immune serum. Responsiveness was partially restored by 850 R whole body irradiation.
摘要
给C57B1小鼠注射内毒素或其他细菌抗原通常会导致：（i）刺激粒细胞和巨噬细胞集落形成的因子血清水平升高；（ii）血液中粒细胞和巨噬细胞祖细胞数量增加。预先给小鼠注射特定物种的聚合鞭毛蛋白会特异性地抑制这两种反应。单次注射鞭毛蛋白后，反应性降低在24小时内开始，持续数月，并且可以通过注射免疫血清被动转移到正常小鼠身上。850拉德的全身照射可部分恢复反应性。
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本文引用的文献
1
ANTIGENS IN IMMUNITY. I. PREPARATION AND PROPERTIES OF FLAGELLAR ANTIGENS FROM SALMONELLA ADELAIDE.免疫中的抗原。一、阿德莱德沙门氏菌鞭毛抗原的制备及特性
Aust J Exp Biol Med Sci. 1964 Jun;42:267-82.
2
Studies on colony formation in vitro by mouse bone marrow cells. II. Action of colony stimulating factor.小鼠骨髓细胞体外集落形成的研究。II. 集落刺激因子的作用。
J Cell Physiol. 1970 Aug;76(1):89-99. doi: 10.1002/jcp.1040760113.
3
Transmural cellular passage in vascular sinuses of rat bone marrow.
Blood. 1970 Aug;36(2):189-208.
4
Antigenic stimulation of bone marrow colony forming cells. 3. Effect in vivo.骨髓集落形成细胞的抗原刺激。3. 体内效应。
Immunology. 1970 Jan;18(1):61-72.
5
The effects of whole body irradiation on serum colony stimulating factor and in vitro colony-forming cells in the bone marrow.全身照射对血清集落刺激因子及骨髓体外集落形成细胞的影响。
Br J Haematol. 1969 Dec;17(6):553-61. doi: 10.1111/j.1365-2141.1969.tb01406.x.
6
Colony-stimulating factor and inhibitor levels in acute granulocytic leukemia.急性粒细胞白血病中的集落刺激因子和抑制因子水平
Blood. 1971 Aug;38(2):143-52.
7
In vitro control of the development of macrophage and granulocyte colonies.巨噬细胞和粒细胞集落发育的体外控制
Proc Natl Acad Sci U S A. 1966 Aug;56(2):488-95. doi: 10.1073/pnas.56.2.488.
8
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J Clin Invest. 1972 Nov;51(11):2981-3. doi: 10.1172/JCI107124.
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