老年小鼠的免疫反应：抗体形成细胞前体和抗原反应性细胞随衰老的变化。
Immune responses in aged mice: changes of antibody-forming cell precursors and antigen-reactive cells with ageing.
作者信息
Kishimoto S, Yamamura Y
出版信息
Clin Exp Immunol. 1971 Jun;8(6):957-62.
Abstract
The depressed immune response to sheep erythrocytes in young syngeneic irradiated recipients, adoptively restored with splenic cells from old donor mice, was used as an index of the changes in the immunocompentent cells with ageing. The numbers of antibody-forming cell precursors in both spleen and bone marrow appeared to be diminished with ageing. Some reduction of antigen-reactive cells was also observed in old spleens.
摘要
将年轻的同基因受照射受体对绵羊红细胞的免疫反应抑制，通过来自老年供体小鼠的脾细胞进行过继性恢复，以此作为免疫活性细胞随年龄变化的指标。脾和骨髓中抗体形成细胞前体的数量似乎随年龄增长而减少。在老年脾脏中也观察到抗原反应性细胞有所减少。
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Immune responses in aged mice: changes of antibody-forming cell precursors and antigen-reactive cells with ageing.老年小鼠的免疫反应：抗体形成细胞前体和抗原反应性细胞随衰老的变化。
Clin Exp Immunol. 1971 Jun;8(6):957-62.
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本文引用的文献
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Relative antibody-forming capacity of spleen cells as a function of age.脾细胞相对抗体形成能力与年龄的关系。
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Plaque formation in agar by single antibody-producing cells.单个产生抗体的细胞在琼脂中形成菌斑。
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Growth and senescence of antibody-forming cells.抗体形成细胞的生长与衰老
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A transplantation assay for mouse cells responsive to antigenic stimulation by sheep erythrocytes.一种针对对绵羊红细胞抗原刺激有反应的小鼠细胞的移植试验。
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Cell migration from the bone marrow to the spleen in young guinea pigs.
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Cell to cell interaction in the immune response. 3. Chromosomal marker analysis of single antibody-forming cells in reconstituted, irradiated, or thymectomized mice.免疫反应中的细胞间相互作用。3. 对重建、照射或胸腺切除小鼠体内的单个抗体形成细胞进行染色体标记分析。
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Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.免疫反应中的细胞间相互作用。II. 给受照射小鼠输注骨髓、胸腺或胸导管淋巴细胞后溶血素形成细胞的来源。
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