Hancock B D, Bowen-Jones E, Dixon R, Dymock I W, Cowley D J
Gut. 1974 Jun;15(6):462-7. doi: 10.1136/gut.15.6.462.
The effect of metoclopramide has been studied on the emptying of solid meals labelled with (51)Cr and monitored with a gamma camera. Metoclopramide, 10 mg iv or a dummy injection, was given randomly and double blind to 10 normal subjects and to 10 patients within three months of a truncal vagotomy and pyloroplasty. All were tested in the recumbent position. Metoclopramide had no effect on emptying rates in the normal subjects nor in four postvagotomy patients who had emptying within the normal range (T(1/2) 30-150 min). In six patients with abnormally delayed emptying (mean T(1/2) 369 min) metoclopramide produced a significant improvement (mean T(1/2) 194 min, p < 0.01).
已对胃复安对用（51）铬标记并通过γ相机监测的固体餐排空的影响进行了研究。将10毫克静脉注射胃复安或安慰剂随机双盲给予10名正常受试者以及10名在进行了迷走神经切断术和幽门成形术三个月内的患者。所有受试者均在卧位进行测试。胃复安对正常受试者以及四名排空在正常范围内（T（1/2）为30 - 150分钟）的迷走神经切断术后患者的排空率没有影响。在六名排空异常延迟（平均T（1/2）为369分钟）的患者中，胃复安产生了显著改善（平均T（1/2）为194分钟，p < 0.01）。
