MacGregor I L, Martin P, Meyer J H
Gastroenterology. 1977 Feb;72(2):206-11.
Alterations in gastric emptying are considered contributory to many sequelae of peptic ulcer surgery. The application of a validated method of firmly tagging solid food has enabled the measurement of the rates and patterns of gastric emptying in normal subjects, subtotal gastrectomy, and vagotomy and pyloroplasty (V&P). Normal persons emptied with a linear pattern at a mean rate of 27.96% per hr. Subtotal gastrectomy patients showed up to three phases in their emptying pattern, which, over all, approximated an exponential pattern with a mean rate constant of 0.030 min-1 and calculated t1/2 of 23.3 min. V&P subjects divided into two groups: (1) slow emptying with a linear pattern and mean rate of 17.64% per hr; (2) rapid emptying with exponential pattern and mean rate constant of 0.039 min-1, t1/2 of 17.7 min. The slow gastric emptying rate and slow passage of chyme through the small intestine in one-half of the V&P group presumably allows greater efficiency of digestion and absorption and may account for the over-all less severe nutritional disturbances after V&P.
胃排空的改变被认为是消化性溃疡手术许多后遗症的成因。应用一种经过验证的牢固标记固体食物的方法，能够测量正常受试者、胃大部切除术患者以及迷走神经切断术和幽门成形术（V&P）患者的胃排空速率和模式。正常个体以每小时27.96%的线性速率排空。胃大部切除术患者的排空模式显示出多达三个阶段，总体上近似指数模式，平均速率常数为0.030分钟-1，计算得出的半衰期为23.3分钟。接受V&P手术的受试者分为两组：（1）排空缓慢，呈线性模式，平均速率为每小时17.64%；（2）排空迅速，呈指数模式，平均速率常数为0.039分钟-1，半衰期为17.7分钟。V&P组中一半患者胃排空速率缓慢且食糜通过小肠的速度较慢，这可能使消化和吸收效率更高，并且可能是V&P术后总体营养紊乱较轻的原因。
