Ferguson R, Asquith P, Cooke W T
Gut. 1974 Jun;15(6):458-61. doi: 10.1136/gut.15.6.458.
Lymphocytes and plasma cells in the lamina propria and lymphocyte in the epithelium have been quantitated in jejunal biopsies from 18 patients with coeliac disease who developed lymphoma. In six patients two or more serial biopsies were available for study. Counts were compared with those obtained in 15 healthy controls and 30 other coeliacs, 15 of whom have been on a gluten-free diet for more than 12 months. Results showed that although the lymphoma patients have abnormal counts compared with controls, they differed from untreated coeliacs in that they had lower plasma cell and higher lymphocyte counts in the lamina propria and lower lymphocyte counts in the epithelium. Such changes tended to be present for up to five years before the diagnosis of lymphoma was made. The results suggest that the immunological status of coeliac patients with lymphoma differs from that of other coeliacs and it could represent a primary abnormality and also be relevant to the development of lymphoma.
对18例患淋巴瘤的乳糜泻患者空肠活检标本中的固有层淋巴细胞、浆细胞以及上皮内淋巴细胞进行了定量分析。其中6例患者有两份或更多份连续活检标本可供研究。将计数结果与15名健康对照者以及30名其他乳糜泻患者的结果进行比较，后者中有15人已进行无麸质饮食超过12个月。结果显示，尽管淋巴瘤患者与对照者相比计数异常，但他们与未经治疗的乳糜泻患者不同，在于其固有层浆细胞计数较低、淋巴细胞计数较高，而上皮内淋巴细胞计数较低。在淋巴瘤诊断前，这些变化往往持续长达五年。结果表明，患淋巴瘤的乳糜泻患者的免疫状态与其他乳糜泻患者不同，这可能代表一种原发性异常，并且也与淋巴瘤的发生有关。
