胰酶肠溶胶囊V强效片与营养酶治疗囊性纤维化吸收不良的对比试验。
Comparative trial of pancrex V forte and nutrizym in treatment of malabsorption in cystic fibrosis.
作者信息
Goodchild M C, Sagaró E, Brown G A, Cruchley P M, Jukes H R, Anderson C M
出版信息
Br Med J. 1974 Sep 21;3(5933):712-4. doi: 10.1136/bmj.3.5933.712.
Abstract
A cross-over trial of pancreatic enzyme replacement therapy has been conducted on 12 children with cystic fibrosis using Pancrex V forte and Nutrizym tablets in equivalent dosage. No differences were found in the effectiveness of these products as measured by stool volume, number of bowel actions, faecal fat excretion, and urine urea excretion. Neither product eliminated the steatorrhoea. Though there was no laboratory evidence to support their choice nine patients expressed a preference for Nutrizym at the conclusion of the trial. This preference was based partly on the smaller number of tablets which are required.
摘要
一项针对12名囊性纤维化儿童的胰腺酶替代疗法交叉试验，使用了等效剂量的V forte胰酶片和Nutrizym片。通过粪便体积、排便次数、粪便脂肪排泄和尿尿素排泄来衡量，这些产品的有效性没有差异。两种产品均未消除脂肪泻。尽管没有实验室证据支持他们的选择，但9名患者在试验结束时表示更喜欢Nutrizym。这种偏好部分基于所需片剂数量较少。
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本文引用的文献
1
Coeliac disease; gastrointestinal studies and the effect of dietary wheat flour.乳糜泻；胃肠道研究及膳食小麦粉的影响
Lancet. 1952 Apr 26;1(6713):836-42. doi: 10.1016/s0140-6736(52)90795-2.
2
A rapid and precise method for the determination of urea.一种快速且精确的尿素测定方法。
J Clin Pathol. 1960 Mar;13(2):156-9. doi: 10.1136/jcp.13.2.156.
3
"Break-through in cystic fibrosis".囊性纤维化研究取得突破
Pediatrics. 1961 Mar;27:351-3.
4
The effect of pancreatin therapy on fat absorption and nitrogen retention in children with fibrocystic disease of the pancreas.胰酶疗法对胰腺纤维囊性病患儿脂肪吸收及氮潴留的影响。
Arch Dis Child. 1955 Oct;30(153):424-7. doi: 10.1136/adc.30.153.424.
5
Fat absorption studies in the diagnosis and treatment of pancreatic fibrosis.脂肪吸收研究在胰腺纤维化诊断与治疗中的应用
Arch Dis Child. 1955 Aug;30(152):316-21. doi: 10.1136/adc.30.152.316.
6
Steatorrhea and azotorrhea and their relation to growth and nutrition in adolescents and young adults with cystic fibrosis.脂肪泻和氮质泻及其与青少年和年轻囊性纤维化患者生长发育和营养状况的关系。
J Pediatr. 1974 Mar;84(3):328-34. doi: 10.1016/s0022-3476(74)80712-2.
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