Beverley D W, Kelleher J, MacDonald A, Littlewood J M, Robinson T, Walters M P
Arch Dis Child. 1987 Jun;62(6):564-8. doi: 10.1136/adc.62.6.564.
Four different pancreatin products, Pancrease, Creon, Pancrex V Forte, and Pancreatin Merck, were compared in a random crossover trial in children with cystic fibrosis. The results of our study showed that patients who received Creon and Pancrease had fewer gastrointestinal symptoms than patients who received Pancrex V Forte and Pancreatin Merck. Fat absorption was significantly improved with Pancrease when compared with Pancrex V forte and Pancreatin Merck. Also the fat absorption with Creon was superior to that with Pancrex V Forte. There was no significant difference in fat absorption between Pancrease and Creon. Pancrex V Forte and Pancreatin Merck, or Pancreatin Merck and Creon. Faecal nitrogen content was less with both Creon and Pancrease compared with Pancreatin Merck. Creon and Pancrease allow the patient with cystic fibrosis to take a high energy diet without any dietary restrictions.
在一项针对囊性纤维化儿童的随机交叉试验中，对四种不同的胰酶产品（胰酶肠溶胶囊、得每通、强力胰酶片和默克胰酶）进行了比较。我们的研究结果表明，接受得每通和胰酶肠溶胶囊的患者胃肠道症状比接受强力胰酶片和默克胰酶的患者少。与强力胰酶片和默克胰酶相比，胰酶肠溶胶囊能显著改善脂肪吸收。而且得每通的脂肪吸收也优于强力胰酶片。胰酶肠溶胶囊和得每通之间的脂肪吸收没有显著差异。强力胰酶片与默克胰酶之间，或默克胰酶与得每通之间也无显著差异。与默克胰酶相比，得每通和胰酶肠溶胶囊的粪便氮含量更低。得每通和胰酶肠溶胶囊使囊性纤维化患者能够在没有任何饮食限制的情况下摄入高能量饮食。
