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多巴胺能终末上突触前胆碱能受体的证据：6-羟基多巴胺变性研究

Evidence for presynaptic cholinergic receptors on dopaminergic terminals: degeneration studies with 6-hydroxydopamine.

作者信息

De Belleroche J, Lugmani Y, Bradford H F

出版信息

Neurosci Lett. 1979 Feb;11(2):209-13. doi: 10.1016/0304-3940(79)90130-7.

DOI:10.1016/0304-3940(79)90130-7
PMID:460689
Abstract

Intraventricular injections of 6-hydroxydopamine (6-OHDA) caused a significant decrease in the tyrosine hydroxylase of striatal synaptosomes of rats, without influencing GABA levels. Significant decreases in the muscarinic and nicotinic receptors also occurred in this preparation after 3 days. The receptors were measured by specific binding studies with N-methylatropine and alpha-bungarotoxin respectively. These results indicate that muscarinic and nicotinic receptors are located on the dopaminergic nerve terminals of corpus striatum.

摘要

脑室内注射6-羟基多巴胺（6-OHDA）可导致大鼠纹状体突触体酪氨酸羟化酶显著降低，而不影响γ-氨基丁酸（GABA）水平。3天后，该制剂中的毒蕈碱型和烟碱型受体也显著减少。分别通过与N-甲基阿托品和α-银环蛇毒素的特异性结合研究来测定这些受体。这些结果表明，毒蕈碱型和烟碱型受体位于纹状体的多巴胺能神经末梢上。

相似文献

1
Evidence for presynaptic cholinergic receptors on dopaminergic terminals: degeneration studies with 6-hydroxydopamine.多巴胺能终末上突触前胆碱能受体的证据：6-羟基多巴胺变性研究
Neurosci Lett. 1979 Feb;11(2):209-13. doi: 10.1016/0304-3940(79)90130-7.
2
Biochemical evidence for the presence of presynaptic receptors on dopaminergic nerve terminals.多巴胺能神经末梢存在突触前受体的生化证据。
Brain Res. 1978 Feb 17;142(1):53-68. doi: 10.1016/0006-8993(78)90176-2.
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Increase in the turnover of brain dopamine by stimulation of muscarinic receptors outside the dopamine nerve terminals.通过刺激多巴胺神经末梢外的毒蕈碱受体增加脑多巴胺的周转率。
J Pharm Pharmacol. 1977 Jul;29(7):435-7. doi: 10.1111/j.2042-7158.1977.tb11360.x.
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Developmental profiles of various cholinergic markers in the rat main olfactory bulb using quantitative autoradiography.利用定量放射自显影术研究大鼠主嗅球中各种胆碱能标志物的发育概况。
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Changes in striatal specific 3-H-atropine binding after unilateral 6-hydroxydopamine lesions of nigrostriatal dopaminergic neurones.黑质纹状体多巴胺能神经元单侧6-羟基多巴胺损伤后纹状体特异性3-H-阿托品结合的变化。
Life Sci. 1978 May 8;22(18):1607-14. doi: 10.1016/0024-3205(78)90056-5.
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Direct binding studies of 125 I-alpha-bungarotoxin and 3H-quinuclidinyl benzilate interaction with axon plasma membrane fragments. Evidence for nicotinic and muscarinic binding sites.125I-α-银环蛇毒素与3H-奎宁环基苯甲酸酯与轴突质膜片段相互作用的直接结合研究。烟碱样和毒蕈碱样结合位点的证据。
Biochem Biophys Res Commun. 1977 Sep 23;78(2):476-82. doi: 10.1016/0006-291x(77)90203-0.
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Release-enhancing pre-synaptic muscarinic and nicotinic receptors co-exist and interact on dopaminergic nerve endings of rat nucleus accumbens.在大鼠伏隔核多巴胺能神经末梢，释放增强型突触前毒蕈碱和烟碱受体共存并相互作用。
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alpha-bungarotoxin-sensitive nicotinic receptors indirectly modulate [(3)H]dopamine release in rat striatal slices via glutamate release.α-银环蛇毒素敏感的烟碱型受体通过谷氨酸释放间接调节大鼠纹状体切片中[³H]多巴胺的释放。
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Sequential changes of cholinergic and dopaminergic receptors in brains after 6-hydroxydopamine lesions of the medial forebrain bundle in rats.大鼠中脑前脑束6-羟基多巴胺损伤后脑内胆碱能和多巴胺能受体的顺序变化
J Neural Transm (Vienna). 2000;107(8-9):873-84. doi: 10.1007/s007020070039.

引用本文的文献

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Role of Ca2+ ions in nicotinic facilitation of GABA release in mouse thalamus.钙离子在小鼠丘脑烟碱样促进γ-氨基丁酸释放中的作用。
J Neurosci. 1997 Jan 15;17(2):576-85. doi: 10.1523/JNEUROSCI.17-02-00576.1997.
2
Cholinergic action in the nucleus accumbens: modulation of dopamine and acetylcholine release.伏隔核中的胆碱能作用：多巴胺和乙酰胆碱释放的调节。
Br J Pharmacol. 1982 Feb;75(2):359-65. doi: 10.1111/j.1476-5381.1982.tb08794.x.
3
Evidence for an inhibitory presynaptic component of neuroleptic drug action.抗精神病药物作用的抑制性突触前成分的证据。
Br J Pharmacol. 1981 Mar;72(3):427-33. doi: 10.1111/j.1476-5381.1981.tb10993.x.
4
Behavioral and biochemical studies of the scopolamine-induced reversal of neuroleptic activity.
Psychopharmacology (Berl). 1981;73(1):17-22. doi: 10.1007/BF00431093.
5
Evidence for a nicotinic component to the actions of acetylcholine in cat visual cortex.猫视觉皮层中乙酰胆碱作用的烟碱成分的证据。
Exp Brain Res. 1988;73(3):553-68. doi: 10.1007/BF00406614.
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Molecular studies of the neuronal nicotinic acetylcholine receptor family.神经元烟碱型乙酰胆碱受体家族的分子研究
Mol Neurobiol. 1987 Winter;1(4):281-337. doi: 10.1007/BF02935740.
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Presynaptic regulation of dopaminergic transmission in the striatum.纹状体中多巴胺能传递的突触前调节。
Cell Mol Neurobiol. 1988 Mar;8(1):7-17. doi: 10.1007/BF00712906.