Mackaness G B, Lagrange P H
J Exp Med. 1974 Sep 1;140(3):865-70. doi: 10.1084/jem.140.3.865.
The T cells which mediate delayed-type hypersensitivity (DTH) to sheep red blood cells (SRBC) are blocked by a normal humoral response and cannot be made to function by further immunization. They can be rescued to some extent by treatment with immunopotentiating agents such as cyclophosphamide (CY) which suppresses the antibody response selectively, or by BCG which interferes with the action of serum blocking factors. These two agents together can restore cell-mediated immunity completely, but a further antigenic stimulus is needed to reestablish DTH in mice blocked by a long period of continuous exposure to SRBC.
介导对绵羊红细胞(SRBC)迟发型超敏反应(DTH)的T细胞会被正常的体液反应所阻断,无法通过进一步免疫使其发挥功能。通过使用免疫增强剂进行治疗,它们可在一定程度上得到挽救,例如选择性抑制抗体反应的环磷酰胺(CY),或干扰血清阻断因子作用的卡介苗(BCG)。这两种药物共同作用可完全恢复细胞介导的免疫,但对于因长期持续接触SRBC而被阻断的小鼠,需要进一步的抗原刺激才能重新建立DTH。