Mackaness G B, Lagrange P H, Ishibashi T
J Exp Med. 1974 Jun 1;139(6):1540-52. doi: 10.1084/jem.139.6.1540.
The inhibition of activated T cells by products of the humoral immune response is almost abolished by systemic infection with BCG. As a result, BCG-infected mice develop very high levels of delayed-type hypersensitivity (DTH) in response to doses of sheep red blood cells (SRBC) that cause complete suppression of DTH in normal mice. This systemic effect of BCG is dose-dependent, and lasts for about 3 wk. Its main effect is to counteract the inhibition of T cells by products of the humoral response. As a result, and in contrast to the T-cell-potentiating effects of cyclophosphamide (CY) which depend on a diminished production of antibodies, increased levels of DTH in BCG-infected mice are associated with increased antibody production. Since BCG and CY act in different ways, their effects are additive. Very remarkable levels of DTH are achieved when they are used in combination.
体液免疫反应产物对活化T细胞的抑制作用几乎被卡介苗全身感染消除。因此，感染卡介苗的小鼠对一定剂量绵羊红细胞（SRBC）产生的迟发型超敏反应（DTH）水平非常高，而相同剂量的绵羊红细胞会使正常小鼠的DTH完全受到抑制。卡介苗的这种全身效应具有剂量依赖性，持续约3周。其主要作用是抵消体液反应产物对T细胞的抑制。因此，与环磷酰胺（CY）增强T细胞的作用（依赖于抗体产生减少）相反，感染卡介苗的小鼠DTH水平升高与抗体产生增加有关。由于卡介苗和环磷酰胺作用方式不同，它们的效应是相加的。当它们联合使用时，可达到非常显著的DTH水平。
