Rawlins M D
Br Med J. 1974 Oct 12;4(5936):91-4. doi: 10.1136/bmj.4.5936.91.
Variability in the response to drugs is due to three principal components-the disease, the responsiveness of tissues, and the concentration of the drug at its site of action (as reflected by its plasma concentration). The relative contributions of these components will differ not only for different drugs but also for different effects of the same drug. Rational drug therapy depends on knowledge of all three factors.
药物反应的变异性归因于三个主要因素——疾病、组织的反应性以及药物在其作用部位的浓度（以血浆浓度反映）。这些因素的相对作用不仅因药物不同而有所差异，而且同一药物的不同效应也存在差异。合理的药物治疗依赖于对所有这三个因素的了解。
