药物反应的变异性。
Variability in response to drugs.
作者信息
Rawlins M D
出版信息
Br Med J. 1974 Oct 12;4(5936):91-4. doi: 10.1136/bmj.4.5936.91.
Abstract
Variability in the response to drugs is due to three principal components-the disease, the responsiveness of tissues, and the concentration of the drug at its site of action (as reflected by its plasma concentration). The relative contributions of these components will differ not only for different drugs but also for different effects of the same drug. Rational drug therapy depends on knowledge of all three factors.
摘要
药物反应的变异性归因于三个主要因素——疾病、组织的反应性以及药物在其作用部位的浓度（以血浆浓度反映）。这些因素的相对作用不仅因药物不同而有所差异，而且同一药物的不同效应也存在差异。合理的药物治疗依赖于对所有这三个因素的了解。
相似文献
1
Variability in response to drugs.药物反应的变异性。
Br Med J. 1974 Oct 12;4(5936):91-4. doi: 10.1136/bmj.4.5936.91.
2
[Spironolactone combined with chlorthalidone in the treatment of essential arterial hypertension].螺内酯联合氯噻酮治疗原发性高血压
Minerva Med. 1975 Apr 21;66(30):1412-6.
3
Plasma nortriptyline levels--relationship to clinical effects.血浆去甲替林水平——与临床疗效的关系
Clin Pharmacol Ther. 1974 Jul;16(1):215-29.
4
Comparison of chlorthalidone and spironolactone in low--renin essential hypertension.氯噻酮与螺内酯治疗低肾素性原发性高血压的比较。
Can Med Assoc J. 1983 Jan 1;128(1):31-4.
5
How to treat arterial hypertension.如何治疗动脉高血压。
Am Fam Physician. 1973 Apr;7(4):99-108.
6
[A comparative study of spironolactone and chlorthalidone in treatment of hypertension].
Lakartidningen. 1974 Jan 16;71(3):175-7.
7
Treatment of depression with tricyclic drugs--pharmacokinetic and pharmacodynamic aspects.三环类药物治疗抑郁症——药代动力学和药效学方面
Pharmakopsychiatr Neuropsychopharmakol. 1976 Jan;9(1):18-26.
8
Plasma nortriptyline levels and ECG findings.血浆去甲替林水平及心电图检查结果。
Am J Psychiatry. 1977 Apr;134(4):441-3. doi: 10.1176/ajp.134.4.441.
9
Plasma nortriptyline and clinical response.
Aust N Z J Psychiatry. 1975 Dec;9(4):249-53. doi: 10.3109/00048677509159858.
10
[Differential diagnosis and therapy of hematuria from the internal medicine standpoint].[内科视角下血尿的鉴别诊断与治疗]
Schweiz Rundsch Med Prax. 1971 May 25;60(21):682-9.
引用本文的文献
1
Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters.液体活检可实现肝脏酶和转运蛋白丰度及个体间变异性的定量分析。
Clin Pharmacol Ther. 2021 Jan;109(1):222-232. doi: 10.1002/cpt.2102. Epub 2020 Nov 25.
2
Ethnicity and psychopharmacology.
Cult Med Psychiatry. 1986 Jun;10(2):151-65. doi: 10.1007/BF00156581.
3
Factors influencing blood concentrations of chlordiazepoxide: a use of multiple regression analysis.
Psychopharmacology (Berl). 1977 Nov 15;54(3):277-82. doi: 10.1007/BF00426576.
本文引用的文献
1
THE INFLUENCE OF ACETYLATOR PHENOTYPE ON THE EFFECTS OF TREATING DEPRESSION WITH PHENELZINE.乙酰化酶表型对苯乙肼治疗抑郁症效果的影响。
Clin Pharmacol Ther. 1965 Jul-Aug;6:430-5. doi: 10.1002/cpt196564430.
2
ENZYMES AND DRUG SENSITIVITY. GLUCOSE 6-PHOSPHATE DEHYDROGENASE DEFICIENCY.酶与药物敏感性。葡萄糖-6-磷酸脱氢酶缺乏症。
Proc R Soc Med. 1964 Jun;57(6):506-8. doi: 10.1177/003591576405700626.
3
HEREDITARY TRANSMISSION OF EXCEPTIONAL RESISTANCE TO COUMARIN ANTICOAGULANT DRUGS. THE FIRST REPORTED KINDRED.遗传性对香豆素抗凝药物的异常抵抗。首例报道的家族系谱。
N Engl J Med. 1964 Oct 15;271:809-15. doi: 10.1056/NEJM196410152711602.
4
HEREDITARY DIAPHORASE DEFICIENCY AND METHEMOGLOBINEMIA.遗传性黄递酶缺乏症与高铁血红蛋白血症
Arch Intern Med. 1964 Apr;113:578-85. doi: 10.1001/archinte.1964.00280100086014.
5
The effects of spironolactone and chlorthalidone on arterial pressure.螺内酯和氯噻酮对动脉血压的影响。
Lancet. 1962 Jun 2;1(7240):1161-4. doi: 10.1016/s0140-6736(62)92199-2.
6
Genetic control of isoniazid metabolism in man.人体中异烟肼代谢的遗传控制。
Br Med J. 1960 Aug 13;2(5197):485-91. doi: 10.1136/bmj.2.5197.485.
7
Clinical and electroencephalographic correlations with serum levels of diphenylhydanotin.临床及脑电图与血清苯妥英水平的相关性
Arch Neurol. 1960 Jun;2:624-30. doi: 10.1001/archneur.1960.03840120030004.
8
A comparison between the behavior of Eskimos and non-Eskimos to the administration of isoniazid.爱斯基摩人与非爱斯基摩人对异烟肼给药的行为比较。
Am Rev Respir Dis. 1960 Apr;81:588-94. doi: 10.1164/arrd.1960.81.4.588.
9
Studies on the metabolism of diphenylhydantoin (Dilantin).二苯妥英（大仑丁）的代谢研究。
Neurology. 1961 May;11:424-9. doi: 10.1212/wnl.11.5.424.
10
Peripheral neuritis due to isoniazid.异烟肼所致周围神经炎
Bull World Health Organ. 1960;23(4-5):587-98.
Zotero 插件