Ratkin G A, Presant C A, Weinerman B, Reinhard E H
Can Med Assoc J. 1974 Nov 2;111(9):924-7.
A staging laparotomy and splenectomy were performed in 41 patients with Hodgkin's disease and 11 with other malignant lymphomas. There was a significant correlation (P = 0.025) between the presence of unexplained anemia and involvement of the spleen or abdominal lymph nodes by tumour. The anemias were of mild degree; hemolysis was documented in three and iron deficiency in four, while 21 cases were unexplained. Bone marrow was not involved by lymphoma in this series. The complication rate in exploratory laparotomy was higher than previously reported. Severe complications were observed in 17% of these patients while another 15% had minor complications. The association we have discovered may be helpful in the staging of patients who cannot tolerate an operative procedure. The absence of infradiaphragmatic involvement is suggested in the presence of normal hemoglobin concentrations.
对41例霍奇金病患者和11例其他恶性淋巴瘤患者进行了分期剖腹术和脾切除术。不明原因贫血的存在与肿瘤累及脾脏或腹部淋巴结之间存在显著相关性（P = 0.025）。贫血程度较轻；3例有溶血记录，4例有缺铁性贫血，21例原因不明。本系列中淋巴瘤未累及骨髓。探查性剖腹术的并发症发生率高于先前报道。17%的患者出现严重并发症，另有15%有轻微并发症。我们发现的这种关联可能有助于对无法耐受手术的患者进行分期。血红蛋白浓度正常提示无膈下受累。
