Rosenberg S A, Dorfman R F, Kaplan H S
Br J Cancer Suppl. 1975 Mar;2:221-7.
The information derived from sequential routine bone marrow biopsies and exploratory laparotomy with splenectomy in 127 consecutive untreated protocol patients with malignant lymphomata other than Hodgkin's disease is reviewed. Of the 61 patients with diffuse lymphomata, 36% changed stage after these diagnostic procedures, usually to a more advanced stage. Of the 66 patients with nodular lymphomata, 62% had a change in stage, almost all to more advanced stages, usually as a result of bone marrow biopsy. The correlation of pathological stages to clinical stages is presented for each of the Rappaport classification subgroups and for several age groups. The precise indications for exploratory laparotomy with splenectomy cannot yet be defined. These will have to await the results of current clinical trials, which may reveal to what degree an improvement in therapeutic results has been achieved as a result of a better knowledge of the extent of disease.
回顾了127例连续接受未经治疗的非霍奇金淋巴瘤方案治疗的患者，通过序贯常规骨髓活检以及剖腹探查加脾切除术所获得的信息。在61例弥漫性淋巴瘤患者中，36%在这些诊断性操作后分期发生改变，通常变为更晚期。在66例结节性淋巴瘤患者中，62%分期发生改变，几乎全部变为更晚期，通常是骨髓活检的结果。针对Rappaport分类的每个亚组以及几个年龄组，给出了病理分期与临床分期的相关性。剖腹探查加脾切除术的确切指征尚未明确。这必须等待当前临床试验的结果，这些结果可能会揭示由于对疾病范围有了更好的了解，治疗效果在何种程度上得到了改善。
