霍乱类毒素可增强人体血清中的大肠杆菌抗毒素。
Cholera toxoid boosts serum Escherichia coli antitoxin in humans.
作者信息
Nalin D R, al-Mahmud A, Curlin G, Ahmed A, Peterson J
出版信息
Infect Immun. 1974 Oct;10(4):747-9. doi: 10.1128/iai.10.4.747-749.1974.
Abstract
Sera from individuals vaccinated with a cholera toxoid were tested to determine if sera with significant titers of cholera antitoxin could neutralize Escherichia coli thermolabile enterotoxin. Individuals who responded to immunization with significant increases in serum cholera antitoxin titers also showed increases in serum E. coli enterotoxin-neutralizing capacity. These findings suggested the possibility that the cholera toxoid vaccine may be useful in preventing disease caused by E. coli.
摘要
对接种霍乱类毒素的个体血清进行检测，以确定具有高滴度霍乱抗毒素的血清是否能中和大肠杆菌不耐热肠毒素。血清霍乱抗毒素滴度因免疫接种而显著升高的个体，其血清大肠杆菌肠毒素中和能力也有所增强。这些发现提示霍乱类毒素疫苗可能有助于预防大肠杆菌所致疾病。
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本文引用的文献
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PASSIVE SERUM PROTECTION OF THE INFANT RABBIT AGAINST EXPERIMENTAL CHOLERA.幼兔被动血清对实验性霍乱的保护作用
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Diarrhea resembling cholera induced by Escherichia coli culture filtrate.大肠杆菌培养滤液诱发的类霍乱腹泻
Lancet. 1973 Mar 24;1(7804):677-8. doi: 10.1016/s0140-6736(73)92255-1.
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