Cohen F L, Daniel W L
J Med Genet. 1974 Sep;11(3):253-6. doi: 10.1136/jmg.11.3.253.
Suspensions of were rapidly agglutinated by serum from cystic fibrosis patients. Serum from obligate heterozygotes exhibited a mean agglutination time that was significantly less than that observed for 128 controls. The agglutinating property was observed to be transmitted through several generations and through both maternal and paternal branches of the pedigrees. Qualitative differences were noted, with CF sera inducing the formation of clumps that were two- to 10-fold larger than those observed in heterozygotes. The serum factor responsible for agglutination was heat sensitive, destroyed by pronase, and neutralized by anti-human whole serum. The CF serum retained agglutinating activity following preincubation with anti-human IgG, IgA, BE, and BA/BC.
囊性纤维化患者的血清能迅速凝集……的悬浮液。 obligate杂合子的血清显示出的平均凝集时间显著短于128名对照者的观察值。观察到这种凝集特性可通过几代人以及家系的母系和父系分支传递。注意到存在定性差异，囊性纤维化血清诱导形成的凝块比杂合子中观察到的凝块大两到十倍。负责……凝集的血清因子对热敏感，被链霉蛋白酶破坏，并被抗人全血清中和。囊性纤维化血清在与抗人IgG、IgA、BE和BA/BC预孵育后仍保留凝集活性。
