Diethelm A G, Dimick A R, Shaw J F, Baker H J, Phillips S J
Ann Surg. 1974 Dec;180(6):814-8. doi: 10.1097/00000658-197412000-00002.
The IgG fraction of equine antithymocyte globulin administered by the intravenous and intramuscular route to two patients with severe thermal injury was associated with survival of the skin allografts to 19 and 42 days. In the second patient the IgG fraction was discontinued 28 days after skin grafting and rejection occurred 14 days later while the patient was receiving azathioprine and 1% topical hydrocortisone cream to the skin allografts. Although no comparison can be made between the immunosuppressive properties of antithymocyte globulin, azathioprine and topical steroids, skin allograft survival was prolonged temporarily until autograft skin from previous donor sites could be obtained. The use of skin allografts protected by immunosuppressive therapy in patients with severe thermal injury deserves further consideration.
通过静脉内和肌肉内途径给两名严重热损伤患者注射马抗胸腺细胞球蛋白的IgG组分，与皮肤同种异体移植物存活至19天和42天相关。在第二名患者中，皮肤移植后28天停用IgG组分，14天后发生排斥反应，此时患者正在接受硫唑嘌呤和用于皮肤同种异体移植物的1%局部氢化可的松乳膏治疗。虽然无法对抗胸腺细胞球蛋白、硫唑嘌呤和局部类固醇的免疫抑制特性进行比较，但皮肤同种异体移植物存活时间暂时延长，直到能够从先前供体部位获取自体移植皮肤。在严重热损伤患者中使用经免疫抑制治疗保护的皮肤同种异体移植物值得进一步考虑。
