核苷酸序列对纺锤菌素与双链DNA的dA.dT特异性结合的影响。
Influence of nucleotide sequence on dA.dT-specific binding of Netropsin to double stranded DNA.
作者信息
Zimmer C, Marck C, Schneider C, Guschlbauer W
出版信息
Nucleic Acids Res. 1979 Jun 25;6(8):2831-7. doi: 10.1093/nar/6.8.2831.
Abstract
Using CD measurements the complex formation of Netropsin (Nt) with poly(dA-dC).poly(dT-dG) and its stability against high salt concentrations is compared with that of poly(dA).poly(dT) and poly(dA-dT).POLY(DT-dA). It is experimentally shown that the insertion of a dG.dC pair in dA.dT sequences strongly reduces the specific interaction of Nt with DNA duplexes. The specificity of the interaction is strongly increased by two or more consecutive thymine residues as present in thymine isostichs of double stranded DNA's.
摘要
使用圆二色光谱测量法，将纺锤菌素（Nt）与聚（dA-dC）·聚（dT-dG）的复合物形成及其在高盐浓度下的稳定性与聚（dA）·聚（dT）和聚（dA-dT）·聚（dT-dA）进行比较。实验表明，在dA.dT序列中插入一个dG.dC对会强烈降低Nt与DNA双链体的特异性相互作用。如双链DNA的胸腺嘧啶同列线中存在的两个或更多连续胸腺嘧啶残基会强烈增加相互作用的特异性。
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