Bardo M T, Hughes R A
Pharmacol Biochem Behav. 1979 Apr;10(4):481-5. doi: 10.1016/0091-3057(79)90221-1.
Rats not exposed to a hot plate with or without morphine and later tested on the functional hot plate with or without morphine, displayed increased paw lick latency relative to same-injected rats given pretest hot plate exposure. This analgesic effect, was termed behavioral analgesia since it, unlike morphine-induced analgesia, was not reversed by naloxone (Experiment 2). Behavioral tolerance was evident in animals exposed to the nonfunctional hot plate regardless of drug treatment and was dissociated from pharmacological tolerance. Behavioral analgesia and tolerance reported here may involve habituation to novel distractive stimuli associated with the hot plate test environment.
未接触有无吗啡的热板，随后在有无吗啡的功能性热板上进行测试的大鼠，相对于在预测试热板暴露后接受相同注射的大鼠，表现出舔爪潜伏期增加。这种镇痛作用被称为行为性镇痛，因为与吗啡诱导的镇痛不同，它不会被纳洛酮逆转（实验2）。无论药物治疗如何，暴露于无功能热板的动物都表现出明显的行为耐受性，并且与药理学耐受性无关。此处报道的行为性镇痛和耐受性可能涉及对与热板测试环境相关的新的分散性刺激的习惯化。
