两栖动物的镇痛：临床前研究与临床应用
Analgesia in amphibians: preclinical studies and clinical applications.
作者信息
Stevens Craig W
机构信息
Department of Pharmacology & Physiology, Oklahoma State University-Center for Health Sciences, 1111 West 17th Street, Tulsa, OK 74107, USA.
出版信息
Vet Clin North Am Exot Anim Pract. 2011 Jan;14(1):33-44. doi: 10.1016/j.cvex.2010.09.007.
Abstract
Preclinical studies of analgesia in amphibians or recommendations for clinical use of analgesics in amphibian species are extremely limited. This article briefly reviews the issues surrounding the use of analgesics in amphibians, starting with common definitions of pain and analgesia when applied to nonhuman animals. Nociceptive and endogenous opioid systems in amphibians are reviewed, and results of preclinical research on opioid and nonopioid analgesics summarized. Recommended opioid and nonopioid analgesics are summarized, and practical recommendations made for their clinical use.
摘要
关于两栖动物镇痛的临床前研究或两栖动物物种镇痛剂临床使用的建议极为有限。本文简要回顾了两栖动物使用镇痛剂的相关问题，首先介绍应用于非人类动物时疼痛和镇痛的常见定义。回顾了两栖动物的伤害感受和内源性阿片系统，并总结了阿片类和非阿片类镇痛剂的临床前研究结果。总结了推荐使用的阿片类和非阿片类镇痛剂，并对其临床使用提出了实际建议。
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本文引用的文献
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J Am Assoc Lab Anim Sci. 2009 Mar;48(2):171-5.
2
The evolution of vertebrate opioid receptors.脊椎动物阿片受体的进化。
Front Biosci (Landmark Ed). 2009 Jan 1;14(4):1247-69. doi: 10.2741/3306.
3
Anesthetic properties of propofol in African clawed frogs (Xenopus laevis).丙泊酚在非洲爪蟾（非洲爪蟾）中的麻醉特性。
J Am Assoc Lab Anim Sci. 2008 Sep;47(5):35-8.
4
A pharmacological comparison of the cloned frog and human mu opioid receptors reveals differences in opioid affinity and function.克隆的青蛙和人类μ阿片受体的药理学比较揭示了阿片类药物亲和力和功能的差异。
Eur J Pharmacol. 2008 Dec 3;599(1-3):36-43. doi: 10.1016/j.ejphar.2008.09.043. Epub 2008 Oct 9.
5
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Pharmacol Biochem Behav. 2009 Jan;91(3):436-40. doi: 10.1016/j.pbb.2008.08.022. Epub 2008 Sep 5.
6
Kinetics and potency of halothane, isoflurane, and desflurane in the Northern Leopard frog Rana pipiens.氟烷、异氟烷和地氟烷在北美豹蛙（Rana pipiens）中的动力学和效能
Vet Res Commun. 2008 Jun;32(5):357-65. doi: 10.1007/s11259-008-9041-2. Epub 2008 Mar 20.
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