化学性白血病发生机制的研究。
Studies on the mechanisms of chemical leukaemogenesis.
作者信息
Dexter T M, Schofield R, Lajtha L G, Moore M
出版信息
Br J Cancer. 1974 Oct;30(4):325-31. doi: 10.1038/bjc.1974.200.
Abstract
Following a single injection of MNU into "intact" mice, a high incidence of leukaemia (90%) is obtained, with a 50% induction time of 200 days. Immunological studies indicate that the θ antigen is expressed on the leukaemic cells. Thymectomized MNU treated mice had a 50% induction time of 500 days, and the incidence was somewhat lower. Leukaemias failed to develop in MNU treated T lymphocyte deficient animals and in lethally irradiated, or thymectomized lethally irradiated mice reconstituted with MNU treated bone marrow. It is suggested that the T lymphocytes rather than the haemopoietic stem cells or pre-T cells are the "target cells" in MNU leukaemogenesis.
摘要
给“完整”小鼠单次注射N-甲基-N-亚硝基脲（MNU）后，白血病发病率很高（90%），50%的诱导时间为200天。免疫学研究表明，白血病细胞上表达θ抗原。经胸腺切除并接受MNU处理的小鼠，50%的诱导时间为500天，发病率略低。在接受MNU处理的T淋巴细胞缺陷动物以及接受致死剂量照射或胸腺切除并接受致死剂量照射后用经MNU处理的骨髓重建的小鼠中，白血病未发生。有人提出，在MNU诱导白血病的过程中，T淋巴细胞而非造血干细胞或前T细胞是“靶细胞”。
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本文引用的文献
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