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1
Ultraviolet mutagenesis and its repair in an Escherichia coli strain containing a nonsense codon.含有无义密码子的大肠杆菌菌株中的紫外线诱变及其修复
Genetics. 1974 Dec;78(4):1035-49. doi: 10.1093/genetics/78.4.1035.
2
Reversions of the two missense and one nonsense trp-mutations induced by UV-light or methyl methanesulfonate in E. coli wild type and its polAi and uvrE502 mutants.
Mutat Res. 1975 Jun;28(3):311-22. doi: 10.1016/0027-5107(75)90225-0.
3
Comparative analysis of deletion and base-change mutabilities of Escherichia coli B strains differing in DNA repair capacity (wild-type, uvrA-, polA-, recA-) by various mutagens.对不同DNA修复能力（野生型、uvrA基因缺陷型、polA基因缺陷型、recA基因缺陷型）的大肠杆菌B菌株经各种诱变剂处理后的缺失和碱基变化突变率进行比较分析。
Mutat Res. 1975 Jan;27(1):27-44. doi: 10.1016/0027-5107(75)90271-7.
4
Biochemical analysis of UV mutagenesis in Escherichia coli by using a cell-free reaction coupled to a bioassay: identification of a DNA repair-dependent, replication-independent pathway.利用与生物测定偶联的无细胞反应对大肠杆菌紫外线诱变进行生化分析：鉴定一种依赖DNA修复、不依赖复制的途径。
Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3300-4. doi: 10.1073/pnas.89.8.3300.
5
Inhibition of excision repair without influence upon UV-sensitivity and UV-mutability in Escherichia coli B/r Hcr+.
Z Naturforsch C Biosci. 1975 May-Jun;30(3):406-11. doi: 10.1515/znc-1975-5-617.
6
Properties of F' factor deoxyribonucleic acid transferred from ultraviolet-irradiated donors: photoreactivation in the recipient and the influence of recA, recB, recC, and uvr genes.从紫外线照射的供体转移的F'因子脱氧核糖核酸的特性：受体中的光复活作用以及recA、recB、recC和uvr基因的影响。
J Bacteriol. 1971 Apr;106(1):143-9. doi: 10.1128/jb.106.1.143-149.1971.
7
Properties of uvrE mutants of Escherichia coli K12. I. Effects of UV irradiation on DNA metabolism.大肠杆菌K12的uvrE突变体的特性。I.紫外线照射对DNA代谢的影响。
Mutat Res. 1974 Dec;25(3):273-9. doi: 10.1016/0027-5107(74)90055-4.
8
Demonstration of UAG as a nonsense codon in bakers' yeast by amino-acid replacements in iso-1-cytochrome c.通过对酵母异-1-细胞色素c进行氨基酸替换来证明UAG在酿酒酵母中作为无义密码子的作用。
J Mol Biol. 1972 Jul 28;68(3):429-43. doi: 10.1016/0022-2836(72)90097-6.
9
Requirement for protein synthesis in rec-dependent repair of deoxyribonucleic acid in Escherichia coli after ultraviolet or X irradiation.紫外线或X射线照射后大肠杆菌中依赖rec的脱氧核糖核酸修复过程中蛋白质合成的需求
J Bacteriol. 1972 Aug;111(2):575-85. doi: 10.1128/jb.111.2.575-585.1972.
10
Transcription-repair coupling determines the strandedness of ultraviolet mutagenesis in Escherichia coli.转录修复偶联决定了大肠杆菌中紫外线诱变的链特异性。
Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):11036-40. doi: 10.1073/pnas.89.22.11036.

引用本文的文献

1
Antagonism of ultraviolet-light mutagenesis by the methyl-directed mismatch-repair system of Escherichia coli.大肠杆菌甲基导向错配修复系统对紫外线诱变的拮抗作用。
Genetics. 2000 Feb;154(2):503-12. doi: 10.1093/genetics/154.2.503.
2
Mutation frequency decline in Escherichia coli. II. Kinetics support the involvement of transcription-coupled excision repair.大肠杆菌中的突变频率下降。II. 动力学支持转录偶联切除修复的参与。
Mol Gen Genet. 1995 Dec 20;249(6):591-9. doi: 10.1007/BF00418028.
3
Mutational specificity of UV light in Escherichia coli: indications for a role of DNA secondary structure.紫外线在大肠杆菌中的突变特异性：DNA二级结构作用的迹象
Proc Natl Acad Sci U S A. 1982 Jul;79(13):4123-7. doi: 10.1073/pnas.79.13.4123.
4
Mutability of bacteriophage M13 by ultraviolet light: role of pyrimidine dimers.紫外线对噬菌体M13的诱变作用：嘧啶二聚体的作用
Mol Gen Genet. 1982;185(3):404-7. doi: 10.1007/BF00334131.
5
Thermal resistance to photoreactivation of specific mutations potentiated in E. coli B/r ung by ultraviolet light.大肠杆菌B/r ung中经紫外线增强的特定突变对光复活的热抗性。
Mol Gen Genet. 1981;182(1):7-11. doi: 10.1007/BF00422759.
6
The role of pyrimidine dimers as premutagenic lesions: a study of targeted vs. untargeted mutagenesis in the lacI gene of Escherichia coli.嘧啶二聚体作为前诱变损伤的作用：大肠杆菌lacI基因中靶向诱变与非靶向诱变的研究。
Genetics. 1984 Mar;106(3):347-64. doi: 10.1093/genetics/106.3.347.
7
Targeted mutation at cytosine-containing pyrimidine dimers: studies of Escherichia coli B/r with acetophenone and 313-nm light.含胞嘧啶嘧啶二聚体的靶向突变：用苯乙酮和313纳米光对大肠杆菌B/r的研究
Proc Natl Acad Sci U S A. 1983 Jul;80(14):4446-9. doi: 10.1073/pnas.80.14.4446.
8
Thermal resistance of UV-mutagenesis to photoreactivation in E. coli B/r uvrA ung: estimate of activation energy and further analysis.大肠杆菌B/r uvrA ung中紫外线诱变对光复活的热抗性：活化能估计及进一步分析
Mol Gen Genet. 1986 Sep;204(3):452-6. doi: 10.1007/BF00331023.
9
Anti-mutagenic effect of ultraviolet light on spontaneous tyrosine tRNA ochre suppressor mutations in Escherichia coli.紫外线对大肠杆菌中自发酪氨酸tRNA赭石型抑制基因突变的抗诱变作用。
Mol Gen Genet. 1988 Oct;214(2):361-4. doi: 10.1007/BF00337737.
10
Differential repair of premutational UV-lesions at tRNA genes in E. coli.大肠杆菌中tRNA基因上突变前紫外线损伤的差异修复
Mol Gen Genet. 1977 Nov 14;156(2):133-40. doi: 10.1007/BF00283485.

本文引用的文献

1
DIFFERENTIAL MUTATION PRODUCTION BY THE DECAY OF INCORPORATED TRITIUM COMPOUNDS IN E. COLI.大肠杆菌中掺入的氚化合物衰变产生的差异突变
Biophys J. 1964 Sep;4(5):355-65. doi: 10.1016/s0006-3495(64)86788-6.
2
Time, temperature, and protein synthesis: a study of ultraviolet-induced mutation in bacteria.时间、温度与蛋白质合成：细菌中紫外线诱导突变的研究
Cold Spring Harb Symp Quant Biol. 1956;21:123-40. doi: 10.1101/sqb.1956.021.01.011.
3
Ultraviolet-induced lethality and reversion to prototrophy in Escherichia coli strains with normal and reduced dark repair ability.紫外线诱导具有正常和降低的暗修复能力的大肠杆菌菌株的致死率及回复为原养型。
Photochem Photobiol. 1965 Jun;4(3):563-8. doi: 10.1111/j.1751-1097.1965.tb09774.x.
4
Exchanges between DNA strands in ultraviolet-irradiated Escherichia coli.紫外线照射的大肠杆菌中DNA链之间的交换
J Mol Biol. 1971 Oct 14;61(1):25-44. doi: 10.1016/0022-2836(71)90204-x.
5
On the specificity of UV mutagenesis in E. coli.
Mutat Res. 1970 Nov;10(5):521-3. doi: 10.1016/0027-5107(70)90015-1.
6
Glycine transfer RNA of Escherichia coli. I. Structural genes for two glycine tRNA species.大肠杆菌的甘氨酸转运RNA。I. 两种甘氨酸tRNA种类的结构基因。
J Mol Biol. 1970 Sep 28;52(3):557-69. doi: 10.1016/0022-2836(70)90419-5.
7
Different modes of loss of photoreversibility of mutation and lethal damage in ultraviolet-light resistant and sensitive bacteria.抗紫外线和紫外线敏感细菌中突变和致死损伤的光可逆性丧失的不同模式。
Mutat Res. 1969 Sep-Oct;8(2):215-28. doi: 10.1016/0027-5107(69)90001-3.
8
Mutagenic effect of sensitized irradiation of bacteriophage T4.噬菌体T4致敏辐射的诱变效应。
J Mol Biol. 1969 Nov 28;46(1):157-67. doi: 10.1016/0022-2836(69)90063-1.
9
Studies on radiation-sensitive mutants of E. coli. 3. Participation of the rec system in induction of mutation by ultraviolet irradiation.大肠杆菌辐射敏感突变体的研究。3. rec 系统在紫外线诱导突变中的作用。
Mol Gen Genet. 1968;103(1):1-10. doi: 10.1007/BF00271151.
10
The conversion of amber suppressors to ochre suppressors.琥珀抑制基因向赭石抑制基因的转变。
Proc Natl Acad Sci U S A. 1968 Jul;60(3):1030-7. doi: 10.1073/pnas.60.3.1030.

含有无义密码子的大肠杆菌菌株中的紫外线诱变及其修复

Ultraviolet mutagenesis and its repair in an Escherichia coli strain containing a nonsense codon.

作者信息

Person S, McCloskey J A, Snipes W, Bockrath R C

出版信息

Genetics. 1974 Dec;78(4):1035-49. doi: 10.1093/genetics/78.4.1035.

DOI:10.1093/genetics/78.4.1035
PMID:4616874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1213237/
Abstract

Ultraviolet mutagenesis and its repair were studied mainly in WU36-10-89, a uvr(-) strain of Escherichia coli containing a UAG mutation in a gene for leucine biosynthesis. Following ultraviolet (UV) irradiation revertants appearing with or without direct photoreactivation (PR) were classified according to the presence and type of suppressor they contained. We find UV mutation production to be quite specific. An analysis of revertants produced by UV indicates they are formed mainly from GC --> AT and that the miscoding is due to a cytosine residue at the site of mutation in a cytosine-thymine (CT) dimer. We propose that the dimer serves as template during some aspects of repair replication and at the time of replication the C in the dimer directs the insertion of A in the complementary strand. We also note that C --> A and T -->G changes caused by a CT dimer occur much less frequently.

摘要

紫外线诱变及其修复主要在大肠杆菌的uvr(-)菌株WU36 - 10 - 89中进行研究，该菌株在亮氨酸生物合成基因中存在UAG突变。紫外线（UV）照射后，出现的回复突变体无论有无直接光复活作用（PR），都根据其所含抑制子的存在情况和类型进行分类。我们发现紫外线诱变产生具有相当的特异性。对紫外线产生的回复突变体的分析表明，它们主要由GC→AT形成，错义编码是由于胞嘧啶 - 胸腺嘧啶（CT）二聚体中突变位点的胞嘧啶残基所致。我们提出，在修复复制的某些方面，二聚体充当模板，并且在复制时，二聚体中的C指导互补链中A的插入。我们还注意到，由CT二聚体引起的C→A和T→G变化发生的频率要低得多。